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  3. CELSR1

CELSR1 (Cadherin EGF LAG seven-pass G-type receptor 1)

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The Function of CELSR1

Receptor that may have an important role in cell/cell signaling during nervous system formation.

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Protein names

Recommended name:

Cadherin EGF LAG seven-pass G-type receptor 1

Alternative name(s):

Cadherin family member 9
Flamingo homolog 2
hFmi2

CELSR1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4044210 (CELSR1) ??
  2. RS5767218 (CELSR1) ??
  3. RS6007897 (CELSR1) ??

Top Gene-Substance Interactions

Substances That Increase CELSR1

Substances Interaction Organism Category

Substances That Decrease CELSR1

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Neural tube defects (NTD): Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. [MIM:182940]

     From NCBI Gene: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008] From UniProt: Receptor that may have an important role in cell/cell signaling during nervous system formation.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-kappaB2

Molecular Function:

  • Calcium Ion Binding
  • G-Protein Coupled Receptor Activity
  • Protein Dimerization Activity
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Anterior/Posterior Pattern Specification
  • Apical Protein Localization
  • Central Nervous System Development
  • Establishment Of Body Hair Planar Orientation
  • Establishment Of Planar Polarity
  • Establishment Of Planar Polarity Of Embryonic Epithelium
  • G-Protein Coupled Receptor Signaling Pathway
  • Hair Follicle Development
  • Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
  • Inner Ear Morphogenesis
  • Lateral Sprouting Involved In Lung Morphogenesis
  • Locomotory Behavior
  • Neural Tube Closure
  • Neuron Migration
  • Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
  • Planar Cell Polarity Pathway Involved In Neural Tube Closure
  • Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
  • Protein Localization Involved In Establishment Of Planar Polarity
  • Regulation Of Actin Cytoskeleton Organization
  • Rho Protein Signal Transduction
  • Wnt Signaling Pathway, Planar Cell Polarity Pathway
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Adgrc1| adhesion G protein-coupled receptor C1| cadherin, EGF LAG seven-pass G-type receptor 1| cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| cadherin EGF LAG seven-pass G-type receptor 1-like protein| cadherin EGF LAG seven-pass G-type receptor precursor-like protein| cadherin family member 9| cadherin-like protein| CB1_000279025| cdhf9| Celsr| c-fmi1| crash| Crsh| flamingo 1| flamingo 2| flamingo homolog 2| flamingo-like protein celsr1| FMI1| fmi2| HFMI2| I79_022382| M959_03098| me2| N308_10073| N312_10879| N322_01749| N329_12041| N340_13554| PAL_GLEAN10004198| protocadherin flamingo 2| Scy| seven-pass transmembrane receptor| UY3_11473| Y1Q_024248| Y956_10484| Z169_08026| celsr1

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