The Function of CELA1
Acts upon elastin.
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Protein names
Recommended name:
Chymotrypsin-like elastase family member 1Alternative name(s):
Elastase-1Pancreatic elastase 1
- RS3951439 (CELA1) ??
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Top Gene-Substance Interactions
Substances That Increase CELA1
| Substances | Interaction | Organism | Category |
Substances That Decrease CELA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Basal layers of epidermis (at protein level). Not expressed in the pancreas.
Caution:
In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase activity described in the pancreas may be in fact due to CELA2A (PubMed:10620133).
Cofactor:
Binds 1 Ca(2+) ion per subunit.
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Inflammatory Response
- Post-Embryonic Development
- Wnt Signaling Pathway
- Exocrine Pancreas Development
- Multicellular Organism Growth
- Regulation Of Cell Proliferation
- Regulation Of Cell Differentiation
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Tissue Remodeling
- Elastin Catabolic Process
- Pancreas Morphogenesis