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  3. CELA1

CELA1 (Chymotrypsin like elastase family member 1)

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The Function of CELA1

Acts upon elastin.

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Protein names

Recommended name:

Chymotrypsin-like elastase family member 1

Alternative name(s):

Elastase-1
Pancreatic elastase 1

CELA1 SNPs

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  1. RS3951439 (CELA1) ??

Top Gene-Substance Interactions

Substances That Increase CELA1

Substances Interaction Organism Category

Substances That Decrease CELA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • c-Myc
  • YY1
  • AREB6
  • USF1
  • NCX/Ncx
  • USF-1

Tissue specificity:

Basal layers of epidermis (at protein level). Not expressed in the pancreas.

Caution:

In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase activity described in the pancreas may be in fact due to CELA2A (PubMed:10620133).

Cofactor:

Binds 1 Ca(2+) ion per subunit.

Molecular Function:

  • Metal Ion Binding
  • Serine-Type Endopeptidase Activity

Biological Processes:

  • Elastin Catabolic Process
  • Exocrine Pancreas Development
  • Inflammatory Response
  • Multicellular Organism Growth
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Pancreas Morphogenesis
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Post-Embryonic Development
  • Regulation Of Cell Differentiation
  • Regulation Of Cell Proliferation
  • Tissue Remodeling
  • Wnt Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_07519| chymotrypsin-like elastase family, member 1| Chymotrypsin-like elastase family member 1| Ela-1| ELA1| ELAI1| elastase-1| elastase 1, pancreatic| elastase I| ELS1| M91_15143| M959_14563| MDA_GLEAN10015517| N300_01364| N301_01239| N306_03801| N312_06811| N321_07983| N326_06472| N332_09117| N333_04553| pancreatic elastase 1| pancreatic elastase I| PANDA_010524| PC-TsF| RATELAI1| XELAEV_18013491mg| Y956_15660| cela1

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