The Function of CEBPB
Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis.
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Protein names
Recommended name:
CCAAT/enhancer-binding protein betaShort name:
LAPAlternative name(s):
C/EBP betaLiver activator protein
Liver-enriched inhibitory protein
LIP
Nuclear factor NF-IL6
Transcription factor 5
TCF-5
Top Gene-Substance Interactions
CEBPB Interacts with These Diseases
| Disease | Score |
Substances That Increase CEBPB
| Substances | Interaction | Organism | Category |
Substances That Decrease CEBPB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at low levels in the lung, kidney and spleen.
Induction:
By ER stress.
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Protein Homodimerization Activity
- Protein Heterodimerization Activity
Biological Processes:
- Ovarian Follicle Development
- Embryonic Placenta Development
- Granuloma Formation
- Regulation Of Transcription, Dna-Templated
- Transcription From Rna Polymerase Ii Promoter
- Acute-Phase Response
- Inflammatory Response
- Immune Response
- Memory
- Neuron Differentiation
- Positive Regulation Of Interleukin-4 Production
- Mammary Gland Epithelial Cell Proliferation
- Response To Endoplasmic Reticulum Stress
- T-Helper 1 Cell Activation
- Negative Regulation Of T Cell Proliferation
- Defense Response To Bacterium
- Negative Regulation Of Neuron Apoptotic Process
- Regulation Of Interleukin-6 Biosynthetic Process
- Positive Regulation Of Fat Cell Differentiation
- Positive Regulation Of Osteoblast Differentiation
- Regulation Of Osteoclast Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Brown Fat Cell Differentiation
- Mammary Gland Epithelial Cell Differentiation
- Regulation Of Transcription Involved In Cell Fate Commitment
- Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
- Cellular Response To Lipopolysaccharide
- Cellular Response To Amino Acid Stimulus
- Cellular Response To Interleukin-1
- Cellular Response To Organic Cyclic Compound
- Hepatocyte Proliferation
- Liver Regeneration
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Endoplasmic Reticulum Stress