The Function of CDX2
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
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Protein names
Recommended name:
Homeobox protein CDX-2Short name:
CDX-3Alternative name(s):
Caudal-type homeobox protein 2Top Gene-Substance Interactions
Substances That Increase CDX2
| Substances | Interaction | Organism | Category |
Substances That Decrease CDX2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Corepressor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- Animal Organ Morphogenesis
- Anterior/Posterior Axis Specification
- Blood Vessel Development
- Cell Differentiation
- Endosome To Lysosome Transport
- Establishment Or Maintenance Of Epithelial Cell Apical/Basal Polarity
- Intestinal Epithelial Cell Differentiation
- Labyrinthine Layer Development
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Cell Differentiation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Transcription, Dna-Templated
- Regulation Of Somitogenesis
- Somatic Stem Cell Population Maintenance
- Transcription From Rna Polymerase Ii Promoter
- Trophectodermal Cell Differentiation