The Function of CDKN3
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
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Protein names
Recommended name:
Cyclin-dependent kinase 3Alternative name(s):
Cell division protein kinase 3- RS2143963 (CDKN3) ??
- RS4251631 (CDKN3) ??
- RS4293296 (CDKN3) ??
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Top Gene-Substance Interactions
Substances That Increase CDKN3
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Substances That Decrease CDKN3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Induction:
Up-regulated in breast and prostate cancer cells.
Molecular Function:
- Protein Serine/Threonine Phosphatase Activity
- Protein Tyrosine/Serine/Threonine Phosphatase Activity
- Protein Tyrosine Phosphatase Activity
- Atp Binding
- Cyclin-Dependent Protein Serine/Threonine Kinase Activity
Biological Processes:
- Cell Cycle Arrest
- G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Cell Proliferation
- Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Cell Division
- Cell Proliferation
- Cellular Response To Dna Damage Stimulus
- G0 To G1 Transition
- Mitotic Nuclear Division