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  3. CDKN2B

CDKN2B (Cyclin dependent kinase inhibitor 2B)

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The Function of CDKN2B

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

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Protein names

Recommended name:

Cyclin-dependent kinase 4 inhibitor B

Short name:

MTS-2

Alternative name(s):

Multiple tumor suppressor 2
p14-INK4b
p15-INK4b
p15INK4B

CDKN2B SNPs

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  1. RS1063192 (CDKN2B) ??
  2. RS3217992 (CDKN2B) ??

Top Gene-Substance Interactions

CDKN2B Interacts with These Diseases

Disease Score

Substances That Increase CDKN2B

Substances Interaction Organism Category

Substances That Decrease CDKN2B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • Sp1
  • HFH-1

Tissue specificity:

Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

Gene Pathways:

  • Disease
  • Pathways in cancer
  • Signal Transduction
  • Gene Expression
  • Cellular responses to stress
  • TGF-beta signaling pathway
  • Small cell lung cancer

Molecular Function:

  • Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity
  • Protein Kinase Binding

Biological Processes:

  • Cell Cycle Arrest
  • Cellular Response To Extracellular Stimulus
  • Cellular Response To Nutrient
  • G2/M Transition Of Mitotic Cell Cycle
  • Megakaryocyte Differentiation
  • Mitotic Cell Cycle Checkpoint
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Epithelial Cell Proliferation
  • Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Negative Regulation Of Phosphorylation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Spleen Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CDK4I| cyclin-dependent kinase inhibitor 2A| cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)| cyclin-dependent kinase inhibitor protein| cdkn2b| cdkn2a/b| 13CDKN2X protein| AV083695| CB1_000790003| CDK4B inhibitor| cdk4l| CDK inhibitory protein| CDKN2A| CDNK2X| cell cycle inhibitor p15| cyclin dependant kinase inhibitor| cyclin-dependent kinase 2B inhibitor| Cyclin-dependent kinase 4 inhibitor B| cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3| cyclin-dependent kinase inhibitor 2B| cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4)| cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)| Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4)| cyclin-dependent kinase inhibitor p15| cyclin-dependent kinase inhibitor p15INK4b| cyclin-dependent kinases 4 and 6 binding protein| EGK_07655| H920_11129| INK4b| MTS2| MTS-2| multiple tumor suppressor 2| p14_CDK inhibitor| p14-INK4b| p14_INK4B| p15| p15 CDK inhibitor| p15ink4b| p15-INK4b| p15(INK4b)| p15_INK4B| p15INK4b cyclin-dependent kinase inhibitor| p15INK4b tumor suppressor| PANDA_005070| TP15| TREES_T100014480

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