The Function of CDKN2B
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
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Protein names
Recommended name:
Cyclin-dependent kinase 4 inhibitor BShort name:
MTS-2Alternative name(s):
Multiple tumor suppressor 2p14-INK4b
p15-INK4b
p15INK4B
- RS1063192 (CDKN2B) ??
- RS3217992 (CDKN2B) ??
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Top Gene-Substance Interactions
CDKN2B Interacts with These Diseases
| Disease | Score |
Substances That Increase CDKN2B
| Substances | Interaction | Organism | Category |
Substances That Decrease CDKN2B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell Cycle Arrest
- Cellular Response To Extracellular Stimulus
- Cellular Response To Nutrient
- G2/M Transition Of Mitotic Cell Cycle
- Megakaryocyte Differentiation
- Mitotic Cell Cycle Checkpoint
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Epithelial Cell Proliferation
- Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Phosphorylation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Spleen Development