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  3. CDKN2A

CDKN2A (Cyclin dependent kinase inhibitor 2A)

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Summary of CDKN2A

The CDKN2A gene encodes several proteins, which includes p16(INK4a) and the p14(ARF) proteins. Both function as tumor suppressors, which means they keep cells from growing and dividing too rapidly or in an uncontrolled way. These proteins help regulate the cell cycle (R).

Mutations of this gene are associated with cancer (R).

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The Function of CDKN2A

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Protein names

Recommended name:

Cyclin-dependent kinase inhibitor 2A

Short name:

CDK4I

Alternative name(s):

Cyclin-dependent kinase 4 inhibitor A
Multiple tumor suppressor 1
MTS-1
p16-INK4a
p16-INK4
p16INK4A

CDKN2A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11515 (CDKN2A) ??
  2. RS3088440 (CDKN2A) ??
  3. RS3731211 (CDKN2A) ??
  4. RS3731217 (CDKN2A) ??
  5. RS3731239 (CDKN2A) ??
  6. RS3731249 (CDKN2A) ??

Top Gene-Substance Interactions

CDKN2A Interacts with These Diseases

Disease Score

Substances That Increase CDKN2A

Substances Interaction Organism Category

Substances That Decrease CDKN2A

Substances Interaction Organism Category

Advanced Summary

     head and neck squamous cell carcinoma Mutations in the CDKN2A gene are found in up to one-quarter of head and neck squamous cell carcinomas (HNSCC). This type of cancerous tumor occurs in the moist lining of the mouth, nose, and throat. CDKN2A gene mutations associated with this condition are acquired during a person's lifetime and are found only in tumor cells; these changes are known as somatic mutations. Most of these mutations lead to production of little or no functional p16(INK4a) protein. Without p16(INK4a) to regulate cell growth and division, cells can continue to grow and divide without control, which can lead to tumor formation. A different type of alteration involving the CDKN2A gene can result in reduced amounts of the p16(INK4a) or p14(ARF) protein. This alteration, known as promoter hypermethylation, turns off the production of p16(INK4a) or p14(ARF). Without one of these tumor suppressors, cells can grow and divide unchecked, leading to the development of cancer. other cancers Mutations affecting the CDKN2A gene are associated with other cancers, including a type of skin cancer called melanoma, breast cancer, lung cancer, and pancreatic cancer. The mutations associated with these cancers are typically inherited (called germline mutations) and are found in all cells in the body. In some families, CDKN2A gene mutations are associated with development of only one type of cancer. In other families, mutations can lead to a cancer predisposition syndrome, which increases the risk of developing multiple types of cancer. CDKN2A gene mutations involved in cancer impair production of functional p16(INK4a) or, less commonly, p14(ARF), which can result in uncontrolled cell growth and tumor formation.

     The CDKN2A gene provides instructions for making several proteins. The most well-studied are the p16(INK4a) and the p14(ARF) proteins. Both function as tumor suppressors, which means they keep cells from growing and dividing too rapidly or in an uncontrolled way. The p16(INK4a) protein attaches (binds) to two other proteins called CDK4 and CDK6. These proteins help regulate the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion. CDK4 and CDK6 normally stimulate the cell to continue through the cycle and divide. However, binding of p16(INK4a) blocks CDK4's or CDK6's ability to stimulate cell cycle progression. In this way, p16(INK4a) controls cell growth and division. The p14(ARF) protein protects a different protein called p53 from being broken down. The p53 protein is an important tumor suppressor that is essential for regulating cell division and self-destruction (apoptosis). By protecting p53, p14(ARF) also helps prevent tumor formation.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • PPAR-gamma1
  • p53
  • AP-1
  • c-Jun
  • Sp1
  • AML1a
  • p300

Tissue specificity:

Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

Gene Pathways:

  • Non-small cell lung cancer
  • Pathways in cancer
  • Bladder cancer
  • Melanoma
  • Cellular responses to stress
  • p53 signaling pathway
  • Glioma
  • Chronic myeloid leukemia
  • Pancreatic cancer

Caution:

The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in term of sequence and function to tumor suppressor ARF (AC Q8N726) which is encoded by the same gene.

Molecular Function:

  • Dna Binding
  • Mdm2/Mdm4 Family Protein Binding
  • P53 Binding
  • Sumo Transferase Activity
  • Transcription Factor Binding
  • Ubiquitin-Protein Transferase Inhibitor Activity
  • Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity
  • Nf-Kappab Binding
  • Poly(A) Rna Binding
  • Protein Kinase Binding

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Apoptotic Mitochondrial Changes
  • Cell Cycle Arrest
  • Cellular Senescence
  • Mitochondrial Depolarization
  • Mitophagy
  • Negative Regulation Of B Cell Proliferation
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Immature T Cell Proliferation In Thymus
  • Negative Regulation Of Protein Kinase Activity
  • Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
  • Negative Regulation Of Ubiquitin-Protein Transferase Activity
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cell Cycle Arrest
  • Positive Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
  • Positive Regulation Of Protein Localization To Nucleus
  • Positive Regulation Of Protein Sumoylation
  • Positive Regulation Of Signal Transduction By P53 Class Mediator
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Destabilization
  • Protein K63-Linked Ubiquitination
  • Protein Polyubiquitination
  • Protein Stabilization
  • Protein Sumoylation
  • Regulation Of Apoptotic Dna Fragmentation
  • Regulation Of G2/M Transition Of Mitotic Cell Cycle
  • Regulation Of Protein Export From Nucleus
  • Regulation Of Protein Stability
  • Regulation Of Protein Targeting To Mitochondrion
  • Rrna Processing
  • Somatic Stem Cell Division
  • Transcription, Dna-Templated
  • G1/S Transition Of Mitotic Cell Cycle
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Cell-Matrix Adhesion
  • Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of Phosphorylation
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Cellular Senescence
  • Positive Regulation Of Macrophage Apoptotic Process
  • Positive Regulation Of Smooth Muscle Cell Apoptotic Process
  • Ras Protein Signal Transduction
  • Replicative Senescence
  • Senescence-Associated Heterochromatin Focus Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

Arf| CDKN2| alternate product p19ARF| alternative reading frame| alternative reading frame p19| ARF-INK4a| ARF tumor suppressor| CDK4I| CDK4 inhibitor p16-INK4| cell cycle inhibitor| cell cycle negative regulator beta| cell cycle regulator| CMM2| cyclin-dependent cell cycle inhibitor| cyclin-dependent kinase 4 inhibitor A| cyclin-dependent kinase inhibitor 2| cyclin-dependent kinase inhibitor 2A| cyclin-dependent kinase inhibitor 2A, isoforms 1/2| cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like protein| cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)| cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)| Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4)| cyclin-dependent kinase inhibitor 2a p16Ink4a| cyclin-dependent kinase inhibitor 2a p19Arf| cyclin-dependent kinase inhibitor protein| INK4| INK4a| Ink4a/Arf| INK4a-ARF| M91_15272| mitochondrial smARF| MLM| MTS1| MTS-1| multiple tumor suppressor 1| P14| p14ARF| p16| p16Cdkn2a| p16-INK4| P16INK4| p16INK4a| p16-INK4a| p16(INK4a)| p16/INK4A cyclin-dependent kinase inhibitor| P19| p19<ARF>| P19ARF| Pctr1| TP16| tumor suppressor CDKN2A| tumor suppressor p13ARF| cdkn2a

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