The Function of CDKN1C
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
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Protein names
Recommended name:
Cyclin-dependent kinase inhibitor 1CAlternative name(s):
Cyclin-dependent kinase inhibitor p57p57Kip2
Top Gene-Substance Interactions
CDKN1C Interacts with These Diseases
| Disease | Score |
Substances That Increase CDKN1C
| Substances | Interaction | Organism | Category |
Substances That Decrease CDKN1C
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Developmental stage:
Expressed within a subset of cells in the subcapsular or developing definitive zone of the adrenal gland.
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal System Development
- Kidney Development
- Cell Cycle Arrest
- Regulation Of Mitotic Cell Cycle
- Aging
- Myeloid Cell Differentiation
- Adrenal Gland Development
- Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Negative Regulation Of Kinase Activity
- Multicellular Organism Growth
- Negative Regulation Of Phosphorylation
- Neuron Maturation
- Camera-Type Eye Development
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Epithelial Cell Proliferation
- Digestive System Development
- Uterus Development
- Embryonic Placenta Morphogenesis
- Genetic Imprinting