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  3. CDKN1C

CDKN1C (Cyclin dependent kinase inhibitor 1C)

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The Function of CDKN1C

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

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Protein names

Recommended name:

Cyclin-dependent kinase inhibitor 1C

Alternative name(s):

Cyclin-dependent kinase inhibitor p57
p57Kip2

Top Gene-Substance Interactions

CDKN1C Interacts with These Diseases

Disease Score

Substances That Increase CDKN1C

Substances Interaction Organism Category

Substances That Decrease CDKN1C

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Developmental stage:

Expressed within a subset of cells in the subcapsular or developing definitive zone of the adrenal gland.

Molecular Function:

  • Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity

Biological Processes:

  • Adrenal Gland Development
  • Aging
  • Camera-Type Eye Development
  • Cell Cycle Arrest
  • Digestive System Development
  • Embryonic Placenta Morphogenesis
  • Genetic Imprinting
  • Kidney Development
  • Multicellular Organism Growth
  • Myeloid Cell Differentiation
  • Negative Regulation Of Epithelial Cell Proliferation
  • Negative Regulation Of Kinase Activity
  • Negative Regulation Of Phosphorylation
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Neuron Maturation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Regulation Of Mitotic Cell Cycle
  • Skeletal System Development
  • Uterus Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CDKI| AL024410| BWCR| BWS| CDN1C| cyclin-dependent kinase inhibitor 1C| cyclin-dependent kinase inhibitor 1C (P57)| cyclin-dependent kinase inhibitor 1C (p57, Kip2)| cyclin-dependent kinase inhibitor 1C pseudogene| cyclin-dependent kinase inhibitor p57| H920_10143| I79_015903| KIP2| p57| p57(kip2)| p57Kip2| p57KIP2 A3sh| PAL_GLEAN10011213| UY3_10014| WBS| cdkn1c

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