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  3. CDH3

CDH3 (Cadherin 3)

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The Function of CDH3

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Protein names

Recommended name:

Cadherin-3

Alternative name(s):

Placental cadherin
P-cadherin

CDH3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS192253604 (CDH3) ??
  2. RS6499188 (CDH3) ??

Top Gene-Substance Interactions

Substances That Increase CDH3

Substances Interaction Organism Category

Substances That Decrease CDH3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • AP-1
  • c-Jun
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1
  • c-Fos
  • AREB6
  • GATA-3

Tissue specificity:

Expressed in some normal epithelial tissues and in some carcinoma cell lines.

Gene Pathways:

  • Cell-Cell communication
  • Cell adhesion molecules (CAMs)

Molecular Function:

  • Calcium Ion Binding

Biological Processes:

  • Adherens Junction Organization
  • Canonical Wnt Signaling Pathway
  • Cell Adhesion
  • Hair Cycle Process
  • Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
  • Keratinization
  • Negative Regulation Of Catagen
  • Negative Regulation Of Transforming Growth Factor Beta2 Production
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Keratinocyte Proliferation
  • Positive Regulation Of Melanin Biosynthetic Process
  • Positive Regulation Of Melanosome Transport
  • Positive Regulation Of Monophenol Monooxygenase Activity
  • Regulation Of Hair Cycle By Canonical Wnt Signaling Pathway
  • Retina Homeostasis
  • Single Organismal Cell-Cell Adhesion
  • Visual Perception
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| B-cadherin| cadherin 15, M-cadherin (myotubule)| cadherin 15, type 1, M-cadherin (myotubule)| Cadherin-3| cadherin-3-like| cadherin 3, P-cadherin (placental)| cadherin-3 preproprotein| cadherin 3, type 1, P-cadherin (placental)| Cadp| calcium-dependent adhesion protein, placental| CB1_000490024| CDH15| Cdhp| D623_10015117| HJMD| I79_011331| K-CAM| M959_05477| MDA_GLEAN10017064| N307_03619| PAL_GLEAN10016268| Pcad| P-cadherin| placental cadherin| RPE-specific cadherin| TREES_T100019726| cdh3

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