The Function of CDH2
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
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Protein names
Recommended name:
Cadherin-2Alternative name(s):
CDw325Neural cadherin
N-cadherin
CD antigen CD325
- RS11083241 (CDH2) ??
- RS11083271 (CDH2) ??
- RS11564386 (CDH2) ??
- RS11659841 (CDH2) ??
- RS2298574 (CDH2) ??
- RS4131805 (CDH2) ??
- RS4800843 (CDH2) ??
- RS879500 (CDH2) ??
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Top Gene-Substance Interactions
CDH2 Interacts with These Diseases
| Disease | Score |
Substances That Increase CDH2
| Substances | Interaction | Organism | Category |
Substances That Decrease CDH2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell Adhesion
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Glial Cell Differentiation
- Calcium-Dependent Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Cerebral Cortex Development
- Regulation Of Myelination
- Adherens Junction Organization
- Regulation Of Rho Protein Signal Transduction
- Positive Regulation Of Mapk Cascade
- Cell-Cell Adhesion Mediated By Cadherin
- Blood Vessel Morphogenesis
- Brain Morphogenesis
- Homeostasis Of Number Of Cells
- Regulation Of Axonogenesis
- Striated Muscle Cell Differentiation
- Positive Regulation Of Muscle Cell Differentiation
- Protein Heterooligomerization
- Radial Glial Cell Differentiation
- Neuroepithelial Cell Differentiation
- Regulation Of Oligodendrocyte Progenitor Proliferation
- Establishment Of Protein Localization To Plasma Membrane
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Neuroligin Clustering Involved In Postsynaptic Membrane Assembly
- Neuronal Stem Cell Population Maintenance
- Regulation Of Postsynaptic Density Protein 95 Clustering
- Positive Regulation Of Synaptic Vesicle Clustering