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  3. CDH2

CDH2 (Cadherin 2)

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The Function of CDH2

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.

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Protein names

Recommended name:

Cadherin-2

Alternative name(s):

CDw325
Neural cadherin
N-cadherin
CD antigen CD325

CDH2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11083241 (CDH2) ??
  2. RS11083271 (CDH2) ??
  3. RS11564386 (CDH2) ??
  4. RS11659841 (CDH2) ??
  5. RS2298574 (CDH2) ??
  6. RS4131805 (CDH2) ??
  7. RS4800843 (CDH2) ??
  8. RS879500 (CDH2) ??

Top Gene-Substance Interactions

CDH2 Interacts with These Diseases

Disease Score

Substances That Increase CDH2

Substances Interaction Organism Category

Substances That Decrease CDH2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1
  • Sp1
  • AP-2gamma
  • Msx-1

Gene Pathways:

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Cell-Cell communication
  • Cell adhesion molecules (CAMs)

Molecular Function:

  • Alpha-Catenin Binding
  • Beta-Catenin Binding
  • Calcium Ion Binding
  • Gamma-Catenin Binding

Biological Processes:

  • Adherens Junction Organization
  • Blood Vessel Morphogenesis
  • Brain Morphogenesis
  • Calcium-Dependent Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
  • Cell Adhesion
  • Cell-Cell Adhesion Mediated By Cadherin
  • Cerebral Cortex Development
  • Establishment Of Protein Localization To Plasma Membrane
  • Glial Cell Differentiation
  • Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
  • Homeostasis Of Number Of Cells
  • Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Neuroepithelial Cell Differentiation
  • Neuroligin Clustering Involved In Postsynaptic Membrane Assembly
  • Neuronal Stem Cell Population Maintenance
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Muscle Cell Differentiation
  • Positive Regulation Of Synaptic Vesicle Clustering
  • Radial Glial Cell Differentiation
  • Regulation Of Oligodendrocyte Progenitor Proliferation
  • Regulation Of Postsynaptic Density Protein 95 Clustering
  • Striated Muscle Cell Differentiation
  • Protein Heterooligomerization
  • Regulation Of Axonogenesis
  • Regulation Of Myelination
  • Regulation Of Rho Protein Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cadherin 1, type 1, E-cadherin (epithelial)| A306_11154| AS27_05865| AS28_00740| cadherin 1, type 1, E-cadherin (epithelial) isoform A| cadherin 1, type 1, E-cadherin (epithelial) isoform B| cadherin-2| cadherin-2-like| cadherin-2-like protein| cadherin 2, neuronal| cadherin-2 preproprotein| cadherin 2, type 1, N-cadherin (neuronal)| cadherin 2, type 1 preproprotein| calcium-dependent adhesion protein, neuronal| CB1_000954021| CD325| CDH1| cdh2-a| cdh2-b| cdhn| CDw325| D623_10026299| EH28_25229| glass onion| glo| GW7_18432| H920_01352| I79_014914| labyrinth| lyr| M91_21275| M959_00927| MDA_GLEAN10014870| N300_12916| N301_10845| N302_00976| N303_04741| N305_03593| N306_12287| N307_09979| N309_01629| N310_07944| N311_06839| N312_10848| N320_13098| N321_10139| N324_06109| N325_10323| N326_02737| N327_01766| N329_04953| N330_13290| N331_05975| N332_02328| N333_12542| N334_03892| N335_00726| N336_03481| N339_03952| N340_00583| N341_02308| Ncad| N-CAD| n-cadherin| N-cadherin 1| neural cadherin| neural-cadherin| neural calcium-dependent cell adhesion molecule| pac| PAL_GLEAN10023138| PANDA_004403| parachute| UY3_06132| Y1Q_010428| Y956_04668| Z169_04960| cdh2

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