The Function of CDH17
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
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Protein names
Recommended name:
Cadherin-17Alternative name(s):
Intestinal peptide-associated transporter HPT-1Liver-intestine cadherin
LI-cadherin
- RS2514805 (CDH17) ??
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Top Gene-Substance Interactions
Substances That Increase CDH17
| Substances | Interaction | Organism | Category |
Substances That Decrease CDH17
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.
Gene Pathways:
Molecular Function:
- Calcium Ion Binding
- Integrin Binding
- Proton-Dependent Oligopeptide Secondary Active Transmembrane Transporter Activity
- Transporter Activity
Biological Processes:
- Adherens Junction Organization
- Calcium-Dependent Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Cell Adhesion
- Germinal Center B Cell Differentiation
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Integrin-Mediated Signaling Pathway
- Marginal Zone B Cell Differentiation
- Oligopeptide Transmembrane Transport
- Oligopeptide Transport
- Positive Regulation Of Integrin Activation By Cell Surface Receptor Linked Signal Transduction
- Spleen Development
- Transport