Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Gene CDH13 - Cahderin 13

The classic gene CHD13 or cadherin-13 protein codes for a member of the cadherin superfamily [R].

Due to their calcium dependency, they play an important role in the construction of tissues and organs. [R].

Since one of cadherins function is to connect cells and tissues, a decrease in the H-cadherin gene is associated with the progression of breast cancer [R].
There are more than 100 members of CDH13 divided into subfamilies, these families are placed in Type I, Type II, desmosomal cadherins, protocadherins, and FAT- cadherins.[R].

The cadherin gene is crucial to the survival of cells, without it cells would not have the shape that they do. [R].
The role of cadherin in the heart is to prevent cell death by the body's imbalance of oxygen containing molecules vs. antioxidants in the body [R].

Cadherin prevents plaque buildup in arteries [R].

T-cadherin is found in the aorta, carotid, iliac, and renal arteries of the heart [R].

Gene CDH13 is mostly found in the extracellular space of a cell, the plasma membrane and in the ER (Endoplasmic Reticulum) [R].

CDH13 is not found in the spinal cord or cerebellum [R].

The effects of smoking and obesity is related to a genetic variant in the CDH13 gene [R].

Studies have shown that the ADHD disease was found in a genetic variant of the CDH13 gene [R].
CDH13 gene variants are linked with psychological disorders, like violent behavior. [R].

Due to cadherin 13 calcium dependency, a diet rich in Calcium is beneficial [R].

Disorders Associated with CDH13:

• ADHD, drug and alcohol abuse, depression, autism disorders,
  schizophrenia, bipolar disorder, violent behavior, and extreme extroverted personalities [R].

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• GR
• GR-alpha
• GR-beta
• p53
• AP-1
• AhR
• c-Jun
• C/EBPbeta
• c-Fos

Tissue specificity:

Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.

Developmental stage:

Expressed at higher levels in adult brain than in developing brain.

Molecular Function:

• Adiponectin Binding
• Cadherin Binding
• Calcium Ion Binding
• Lipoprotein Particle Binding
• Low-Density Lipoprotein Particle Binding

Biological Processes:

• Adherens Junction Organization
• Calcium-Dependent Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
• Endothelial Cell Migration
• Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
• Keratinocyte Proliferation
• Lamellipodium Assembly
• Localization Within Membrane
• Low-Density Lipoprotein Particle Mediated Signaling
• Mitotic Cell Cycle
• Negative Regulation Of Cell Adhesion
• Negative Regulation Of Cell Proliferation
• Positive Regulation Of Calcium-Mediated Signaling
• Positive Regulation Of Cell-Matrix Adhesion
• Positive Regulation Of Cell Migration
• Positive Regulation Of Endothelial Cell Proliferation
• Positive Regulation Of Positive Chemotaxis
• Positive Regulation Of Smooth Muscle Cell Proliferation
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Rac Protein Signal Transduction
• Regulation Of Endocytosis
• Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
• Rho Protein Signal Transduction
• Sprouting Angiogenesis

*synonyms