Summary of CDH13
CDH13 gene encodes a member of the cadherin superfamily. The protein acts as a negative regulator of axon growth during neural differentiation, protects vascular endothelial cells from cell death due to oxidative stress, and is associated with resistance to atherosclerosis (high cholesterol) (R).
This gene is associated with risk of cancer (R).
The Function of CDH13
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
Protein names
Recommended name:
Cadherin-13Short name:
P105Alternative name(s):
Heart cadherinH-cadherin
Truncated cadherin
T-cad
T-cadherin
- RS10514550 (CDH13) ??
- RS10514585 (CDH13) ??
- RS11644424 (CDH13) ??
- RS11646213 (CDH13) ??
- RS11646411 (CDH13) ??
- RS11649622 (CDH13) ??
- RS12051272 (CDH13) ??
- RS12386026 (CDH13) ??
- RS12446301 (CDH13) ??
- RS12598815 (CDH13) ??
- RS12933472 (CDH13) ??
- RS139419280 (CDH13) ??
- RS149740259 (CDH13) ??
- RS16958145 (CDH13) ??
- RS16958148 (CDH13) ??
- RS17216786 (CDH13) ??
- RS17675602 (CDH13) ??
- RS3096277 (CDH13) ??
- RS3784943 (CDH13) ??
- RS3784962 (CDH13) ??
- RS3844412 (CDH13) ??
- RS3865188 (CDH13) ??
- RS4074373 (CDH13) ??
- RS41389746 (CDH13) ??
- RS444881 (CDH13) ??
- RS4783244 (CDH13) ??
- RS6563898 (CDH13) ??
- RS6563943 (CDH13) ??
- RS8055236 (CDH13) ??
- RS8056064 (CDH13) ??
- RS8057927 (CDH13) ??
- RS9922134 (CDH13) ??
- RS9934935 (CDH13) ??
- RS9939760 (CDH13) ??
- RS9940464 (CDH13) ??
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Top Gene-Substance Interactions
CDH13 Interacts with These Diseases
Disease | Score |
Substances That Increase CDH13
Substances | Interaction | Organism | Category |
Substances That Decrease CDH13
Substances | Interaction | Organism | Category |
Advanced Summary
Gene CDH13 - Cahderin 13
The classic gene CHD13 or cadherin-13 protein codes for a member of the cadherin superfamily [R].
Due to their calcium dependency, they play an important role in the construction of tissues and organs. [R].
Since one of cadherins function is to connect cells and tissues, a decrease in the H-cadherin gene is associated with the progression of
breast cancer
[R].
There are more than 100 members of CDH13 divided into subfamilies, these families are placed in Type I, Type II, desmosomal cadherins, protocadherins, and FAT- cadherins.[R].
The cadherin gene is crucial to the survival of cells, without it cells would not have the shape that they do. [R].
The role of cadherin in the heart is to prevent cell death by the body's imbalance of oxygen containing molecules vs. antioxidants in the body [R].
Cadherin prevents plaque buildup in arteries [R].
T-cadherin is found in the aorta, carotid, iliac, and renal arteries of the heart [R].
Gene CDH13 is mostly found in the extracellular space of a cell, the plasma membrane and in the ER (Endoplasmic Reticulum) [R].
CDH13 is not found in the spinal cord or cerebellum [R].
The effects of smoking and obesity is related to a genetic variant in the CDH13 gene [R].
Studies have shown that the ADHD disease was found in a genetic variant of the CDH13 gene [R].
CDH13 gene variants are linked with psychological disorders, like violent behavior. [R].
Due to cadherin 13 calcium dependency, a diet rich in Calcium is beneficial [R].
Disorders Associated with CDH13:
-
ADHD, drug and alcohol abuse, depression, autism disorders,
schizophrenia, bipolar disorder, violent behavior, and extreme extroverted personalities [R].
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.
Gene Pathways:
Developmental stage:
Expressed at higher levels in adult brain than in developing brain.
Molecular Function:
- Adiponectin Binding
- Cadherin Binding
- Calcium Ion Binding
- Lipoprotein Particle Binding
- Low-Density Lipoprotein Particle Binding
Biological Processes:
- Adherens Junction Organization
- Calcium-Dependent Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Endothelial Cell Migration
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Keratinocyte Proliferation
- Lamellipodium Assembly
- Localization Within Membrane
- Low-Density Lipoprotein Particle Mediated Signaling
- Mitotic Cell Cycle
- Negative Regulation Of Cell Adhesion
- Negative Regulation Of Cell Proliferation
- Positive Regulation Of Calcium-Mediated Signaling
- Positive Regulation Of Cell-Matrix Adhesion
- Positive Regulation Of Cell Migration
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Positive Chemotaxis
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Rac Protein Signal Transduction
- Regulation Of Endocytosis
- Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Rho Protein Signal Transduction
- Sprouting Angiogenesis