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  3. CDC6

CDC6 (Cell division cycle 6)

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The Function of CDC6

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

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Protein names

Recommended name:

Cell division control protein 6 homolog

Alternative name(s):

CDC6-related protein
Cdc18-related protein
HsCdc18
p62(cdc6
HsCDC6

CDC6 SNPs

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  1. RS13706 (CDC6) ??

Top Gene-Substance Interactions

CDC6 Interacts with These Diseases

Disease Score

Substances That Increase CDC6

Substances Interaction Organism Category

Substances That Decrease CDC6

Substances Interaction Organism Category

Advanced Summary

     Meier-Gorlin syndrome At least one mutation in the CDC6 gene causes Meier-Gorlin syndrome, a condition characterized by short stature, underdeveloped kneecaps, and small ears. This mutation, which is a rare cause of the condition, changes a single protein building block (amino acid) in the CDC6 protein, replacing the amino acid threonine at position 323 with the amino acid arginine (written as Thr323Arg). As a result, assembly of the pre-replication complex is impaired, which disrupts replication licensing; however, it is not clear how a reduction in replication licensing leads to Meier-Gorlin syndrome. Researchers speculate that such a reduction delays the cell division process, which slows growth of the bones and other tissues during development. It is not known why development of the kneecaps and ears is particularly affected in Meier-Gorlin syndrome.

     The CDC6 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). The protein produced from this gene, called cell division cycle 6 or CDC6, is one of a group of proteins known as the pre-replication complex. In a multi-step process, the components of this complex attach (bind) to certain regions of DNA known as origins of replication (or origins), where the process of DNA copying begins. When the pre-replication complex is attached to the origin, replication is able to begin at that location. This tightly controlled process, called replication licensing, helps ensure that DNA replication occurs only once per cell division and is required for cells to divide.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • E2F-1
  • YY1

Gene Pathways:

  • DNA Replication

Molecular Function:

  • Atp Binding
  • Kinase Binding
  • Nucleotide Binding

Biological Processes:

  • Cell Division
  • Cellular Response To Angiotensin
  • Cellular Response To Vasopressin
  • Dna Replication
  • Dna Replication Checkpoint
  • Dna Replication Initiation
  • G1/S Transition Of Mitotic Cell Cycle
  • Mitotic Nuclear Division
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Dna Replication
  • Positive Regulation Of Chromosome Segregation
  • Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Positive Regulation Of Cytokinesis
  • Positive Regulation Of Fibroblast Proliferation
  • Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Regulation Of Mitotic Metaphase/Anaphase Transition
  • Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
  • Traversing Start Control Point Of Mitotic Cell Cycle
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_15425| CDC18L| cdc18-related protein| CDC18(S.pombe)| CDC6 cell division cycle 6 homolog| CDC6 homolog| Cdc6-PA| CDC6-related protein| Cell division control protein 6| cell division control protein 6 homolog| Cell division control protein 6 like protein| Cell division control protein 6-like protein| cell division cycle 6 homolog| cell division cycle 6 homolog (S. cerevisiae)| cell division cycle 6-like protein| cell division cycle 6 protein| CG5971 gene product from transcript CG5971-RA| CG5971-PA| DmCdc6| Dmel_CG5971| HsCDC18| HsCDC6| M959_05803| MGORS5| N300_06126| N305_13457| p62(cdc6)| PANDA_014404| Retinoic acid receptor alpha| UY3_09141| xcdc6| Y1Q_015110| cdc6

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