Summary of CD86
This gene encodes a protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells and helps activate the T-cell (R).
0 users want this gene increased,
0 users want it decreased
The Function of CD86
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Protein names
Recommended name:
T-lymphocyte activation antigen CD86Short name:
B70Alternative name(s):
Activation B7-2 antigenBU63
CTLA-4 counter-receptor B7.2
FUN-1
CD antigen CD86
- RS1129055 (CD86) ??
- RS17281995 (CD86) ??
- RS2681411 (CD86) ??
- RS2681416 (CD86) ??
- RS4308217 (CD86) ??
- RS9282641 (CD86) ??
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Top Gene-Substance Interactions
CD86 Interacts with These Diseases
| Disease | Score |
Substances That Increase CD86
| Substances | Interaction | Organism | Category |
Substances That Decrease CD86
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed by activated B-lymphocytes and monocytes.
Gene Pathways:
- Disease
- Immune System
- Signal Transduction
- Autoimmune thyroid disease
- Toll-like receptor signaling pathway
- Cell adhesion molecules (CAMs)
- Allograft rejection
- Graft-versus-host disease
- Intestinal immune network for IgA production
- Rheumatoid arthritis
- Type I diabetes mellitus
- Systemic lupus erythematosus
- Viral myocarditis
Molecular Function:
- Coreceptor Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Receptor Activity
- Virus Receptor Activity
Biological Processes:
- Adaptive Immune Response
- Aging
- B Cell Activation
- Cell-Cell Signaling
- Cellular Response To Cytokine Stimulus
- Cellular Response To Lipopolysaccharide
- Cellular Response To Metal Ion
- Defense Response To Virus
- Immune Response
- Myeloid Dendritic Cell Differentiation
- Negative Regulation Of T Cell Anergy
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Interleukin-2 Biosynthetic Process
- Positive Regulation Of Interleukin-4 Biosynthetic Process
- Positive Regulation Of Lymphotoxin A Biosynthetic Process
- Positive Regulation Of T-Helper 2 Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Response To Interferon-Gamma
- Response To Yeast
- T Cell Activation
- T Cell Costimulation
- T Cell Proliferation Involved In Immune Response
- Toll-Like Receptor 3 Signaling Pathway
Drug Bank:
- Abatacept
- Anti-Thymocyte Globulin (Rabbit)
- Belatacept