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  3. CD55

CD55 (CD55 molecule (Cromer blood group))

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The Function of CD55

(Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274).

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Protein names

Recommended name:

Complement decay-accelerating factor

Alternative name(s):

CD antigen CD55

CD55 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10746463 (CD55) ??
  2. RS2564978 (CD55) ??

Top Gene-Substance Interactions

CD55 Interacts with These Diseases

Disease Score

Substances That Increase CD55

Substances Interaction Organism Category

Substances That Decrease CD55

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Cromer blood group system

     From NCBI Gene: This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014] From UniProt: (Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274). This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Fos
  • TBP
  • IRF-2
  • TFIID

Tissue specificity:

Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.

Gene Pathways:

  • Immune System
  • Signal Transduction
  • Hematopoietic cell lineage
  • Complement and coagulation cascades
  • Viral myocarditis

Molecular Function:

  • Lipid Binding
  • Virus Receptor Activity

Biological Processes:

  • Cd4-Positive, Alpha-Beta T Cell Cytokine Production
  • Complement Activation, Classical Pathway
  • Er To Golgi Vesicle-Mediated Transport
  • Innate Immune Response
  • Negative Regulation Of Complement Activation
  • Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Activation
  • Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Proliferation
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Regulation Of Complement Activation
  • Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
  • Respiratory Burst

Drug Bank:

  • Chloramphenicol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| C4b-binding protein alpha chain| CR| AS28_04562| CD55 antigen| CD55 molecule| CD55 molecule, decay accelerating factor for complement| CD55 molecule, decay accelerating factor for complement (Cromer blood group)| complement decay-accelerating factor| complement decay-accelerating factor, GPI-anchored| complement decay-accelerating factor isoform 1 preproprotein| complement decay-accelerating factor-like| Complement decay-accelerating factor transmembrane isoform| complement-glycosylphosphatidylinositol| Complement receptor type 1| Complement receptor type 2| CROM| Cromer blood group| DAF| Daf1| Daf-GPI| decay-accelarating factor| decay accelarating factor 1| decay accelerating factor| decay-accelerating factor| decay accelerating factor 1| decay-accelerating factor 1| decay-accelerating factor CD55| decay accelerating factor for complement| decay-accelerating factor (GDab-TCS)| decay accelerating factor GPI-form| glycosylphophatidylinositol-anchored form| GPI anchor addition signal| GPI-DAF| H920_18969| I79_003362| N306_00484| N320_06374| N326_09933| N330_07804| N333_02984| N336_05797| N340_06863| PANDA_018751| TC| TREES_T100003447| cd55

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