From NCBI Gene: Cromer blood group system

     From NCBI Gene: This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014] From UniProt: (Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274). This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.

The following transcription factors affect gene expression:

• PPAR-alpha
• HNF-4alpha1
• HNF-4alpha2
• c-Fos
• TBP
• IRF-2
• TFIID

Tissue specificity:

Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.

Molecular Function:

• Lipid Binding
• Virus Receptor Activity

Biological Processes:

• Cd4-Positive, Alpha-Beta T Cell Cytokine Production
• Complement Activation, Classical Pathway
• Er To Golgi Vesicle-Mediated Transport
• Innate Immune Response
• Negative Regulation Of Complement Activation
• Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Activation
• Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Proliferation
• Positive Regulation Of Cytosolic Calcium Ion Concentration
• Regulation Of Complement Activation
• Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
• Respiratory Burst

Drug Bank:

• Chloramphenicol