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  3. CD44

CD44 (CD44 molecule (Indian blood group))

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Summary of CD44

CD44 encodes a protein that is involved in cell-cell interactions, cell adhesion, and migration. It interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs) (R).

It can be used as a marker for memory cells as well as breast, prostate, and ovarian cancer cells (R). High levels of CD44 expression may lead to some types of cancer (R). 

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The Function of CD44

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.

Protein names

Recommended name:

CD44 antigen

Alternative name(s):

CDw44
Epican
Extracellular matrix receptor III
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Heparan sulfate proteoglycan
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
PGP-1
Phagocytic glycoprotein I
PGP-I
CD antigen CD44

CD44 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12419062 (CD44) ??
  2. RS1467558 (CD44) ??
  3. RS187116 (CD44) ??
  4. RS8193 (CD44) ??
  5. RS996076 (CD44) ??

Top Gene-Substance Interactions

CD44 Interacts with These Diseases

Disease Score

Substances That Increase CD44

Substances Interaction Organism Category

Substances That Decrease CD44

Substances Interaction Organism Category

Advanced Summary

CD44 encodes a protein that is involved in cell-cell interactions, cell adhesion, and migration. It interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs) (R).

It can be used as a marker for memory cells as well as breast, prostate, and ovarian cancer cells (R). High levels of CD44 expression may lead to some types of cancer (R). 

     From NCBI Gene: INDIAN BLOOD GROUP SYSTEM

     From NCBI Gene: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] From UniProt: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • AP-1
  • c-Jun
  • NF-kappaB1
  • c-Fos

Tissue specificity:

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Gene Pathways:

  • Metabolism
  • Disease
  • Immune System
  • Hemostasis
  • Extracellular matrix organization
  • Shigellosis
  • Hematopoietic cell lineage

Molecular Function:

  • Collagen Binding
  • Hyaluronic Acid Binding

Biological Processes:

  • Cartilage Development
  • Cell-Matrix Adhesion
  • Cellular Response To Fibroblast Growth Factor Stimulus
  • Extracellular Matrix Disassembly
  • Extracellular Matrix Organization
  • Hyaluronan Catabolic Process
  • Interferon-Gamma-Mediated Signaling Pathway
  • Leukocyte Migration
  • Monocyte Aggregation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Negative Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage By P53 Class Mediator
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Heterotypic Cell-Cell Adhesion
  • Positive Regulation Of Monocyte Aggregation
  • Positive Regulation Of Peptidyl-Serine Phosphorylation
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Single Organismal Cell-Cell Adhesion

Drug Bank:

  • Hyaluronic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11419| AS27_11460| AS28_05420| CB1_056579017| CD44A| CD44 antigen| CD44 antigen (homing function and Indian blood group system)| CD44 antigen isoform d6-12| CD44 antigen isoform d6-13| CD44 antigen isoform d6-15| CD44 antigen-like protein| CD44-like protein| CD44 molecule| cdw44| cell surface glycoprotein CD44| Cell surface glycoprotein CD44 (hyaluronate binding protein)| chondroitin sulfate proteoglycan 8| cspg8| D623_10030939| ecmr-iii| EGK_06355| epican| extracellular matrix receptor-III| Extracellular matrix receptor III| GP90 lymphocyte homing/adhesion receptor| H920_18756| HAM1 antigen| hcell| hematopoietic cell E- and L-selectin ligand| heparan sulfate proteoglycan| HERMES| hermes antigen| homing function and Indian blood group system| HUTCH-I| hyaluronate receptor| I79_003042| IN| LHR| Ly-24| lymphocyte antigen 24| lymphocyte surface antigen precursor CD44| M91_01245| M959_02318| mc56| MDA_GLEAN10011619| mdu2| mdu3| METAA| MIC4| mutch-i| N300_01954| N301_15993| N302_01519| N303_00231| N305_03438| N306_09613| N307_09663| N308_05660| N309_08104| N311_10928| N312_11022| N321_13013| N331_12229| N335_14348| N340_12451| N341_10366| PAL_GLEAN10018057| PANDA_009413| Pgp1| Pgp-1| PGP-I| phagocytic glycoprotein 1| phagocytic glycoprotein I| RHAMM| soluble CD44| UY3_02702| XCD44| Y1Q_017733| Y956_14752| Z169_07905| cd44

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