The Function of CD40
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Protein names
Recommended name:
Tumor necrosis factor receptor superfamily member 5Alternative name(s):
B-cell surface antigen CD40Bp50
CD40L receptor
CDw40
CD antigen CD40
- RS12480534 (CD40) ??
- RS1535045 (CD40) ??
- RS1569723 (CD40) ??
- RS1883832 (CD40) ??
- RS4239702 (CD40) ??
- RS4810485 (CD40) ??
- RS4813003 (CD40) ??
- RS6032662 (CD40) ??
- RS6074022 (CD40) ??
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Top Gene-Substance Interactions
CD40 Interacts with These Diseases
Disease | Score |
Substances That Increase CD40
Substances | Interaction | Organism | Category |
Substances That Decrease CD40
Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: rheumatoid arthritisGraves diseaseFrom NCBI Gene: Immunodeficiency with hyper IgM type 3From UniProt: Immunodeficiency with hyper-IgM 3 (HIGM3): A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. [MIM:606843]
From NCBI Gene: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] From UniProt: Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
B-cells and in primary carcinomas.
Gene Pathways:
- Immune System
- Autoimmune thyroid disease
- Cytokine-cytokine receptor interaction
- Toll-like receptor signaling pathway
- Cell adhesion molecules (CAMs)
- Toxoplasmosis
- Allograft rejection
- Asthma
- Intestinal immune network for IgA production
- Malaria
- Primary immunodeficiency
- Systemic lupus erythematosus
- Viral myocarditis
Molecular Function:
- Antigen Binding
- Enzyme Binding
- Receptor Activity
- Signal Transducer Activity
- Tumor Necrosis Factor-Activated Receptor Activity
- Ubiquitin Protein Ligase Binding
Biological Processes:
- Apoptotic Signaling Pathway
- B Cell Proliferation
- Cellular Calcium Ion Homeostasis
- Cellular Response To Lipopolysaccharide
- Cellular Response To Mechanical Stimulus
- Defense Response To Protozoan
- Defense Response To Virus
- Immune Response
- Immune Response-Regulating Cell Surface Receptor Signaling Pathway
- Inflammatory Response
- Multicellular Organism Development
- Platelet Activation
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Endothelial Cell Apoptotic Process
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of Protein Kinase C Signaling
- Positive Regulation Of Protein Phosphorylation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Protein Complex Assembly
- Protein Kinase B Signaling
- Regulation Of Cell Proliferation
- Regulation Of Immune Response
- Regulation Of Immunoglobulin Secretion
- Response To Lipopolysaccharide
- Tumor Necrosis Factor-Mediated Signaling Pathway