The Function of CD3E
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).
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Protein names
Recommended name:
T-cell surface glycoprotein CD3 epsilon chainAlternative name(s):
T-cell surface antigen T3/Leu-4 epsilon chainCD antigen CD3e
- RS17122021 (CD3E) ??
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Top Gene-Substance Interactions
CD3E Interacts with These Diseases
| Disease | Score |
Substances That Increase CD3E
| Substances | Interaction | Organism | Category |
Substances That Decrease CD3E
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Heterodimerization Activity
- Protein Kinase Binding
- Receptor Signaling Complex Scaffold Activity
- Sh3 Domain Binding
- Signal Transducer Activity, Downstream Of Receptor
- T Cell Receptor Binding
- Transmembrane Signaling Receptor Activity
Biological Processes:
- Apoptotic Signaling Pathway
- Cell Surface Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway
- Negative Regulation Of Gene Expression
- Negative Regulation Of Smoothened Signaling Pathway
- Negative Thymic T Cell Selection
- Positive Regulation Of Alpha-Beta T Cell Proliferation
- Positive Regulation Of Calcium-Mediated Signaling
- Positive Regulation Of Gene Expression
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-2 Biosynthetic Process
- Positive Regulation Of Interleukin-4 Production
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of T Cell Anergy
- Positive Regulation Of T Cell Proliferation
- Protein Complex Assembly
- Regulation Of Apoptotic Process
- Regulation Of Immune Response
- Response To Nutrient
- Signal Complex Assembly
- T Cell Activation
- T Cell Costimulation
- T Cell Receptor Signaling Pathway
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Drug Bank:
- Muromonab