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  3. CD3E

CD3E (CD3e molecule)

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The Function of CD3E

The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).

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Protein names

Recommended name:

T-cell surface glycoprotein CD3 epsilon chain

Alternative name(s):

T-cell surface antigen T3/Leu-4 epsilon chain
CD antigen CD3e

CD3E SNPs

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  1. RS17122021 (CD3E) ??

Top Gene-Substance Interactions

CD3E Interacts with These Diseases

Disease Score

Substances That Increase CD3E

Substances Interaction Organism Category

Substances That Decrease CD3E

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR

Gene Pathways:

  • Immune System
  • Measles
  • T cell receptor signaling pathway
  • Chagas disease (American trypanosomiasis)
  • Hematopoietic cell lineage
  • Primary immunodeficiency

Molecular Function:

  • Protein Heterodimerization Activity
  • Protein Kinase Binding
  • Receptor Signaling Complex Scaffold Activity
  • Sh3 Domain Binding
  • Signal Transducer Activity, Downstream Of Receptor
  • T Cell Receptor Binding
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Apoptotic Signaling Pathway
  • Cell Surface Receptor Signaling Pathway
  • G-Protein Coupled Receptor Signaling Pathway
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Smoothened Signaling Pathway
  • Negative Thymic T Cell Selection
  • Positive Regulation Of Alpha-Beta T Cell Proliferation
  • Positive Regulation Of Calcium-Mediated Signaling
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-2 Biosynthetic Process
  • Positive Regulation Of Interleukin-4 Production
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of T Cell Anergy
  • Positive Regulation Of T Cell Proliferation
  • Protein Complex Assembly
  • Regulation Of Apoptotic Process
  • Regulation Of Immune Response
  • Response To Nutrient
  • Signal Complex Assembly
  • T Cell Activation
  • T Cell Costimulation
  • T Cell Receptor Signaling Pathway
  • Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway

Drug Bank:

  • Muromonab
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14337| Anapl_06491| antigen CD3E, epsilon polypeptide (TiT3 complex)| AS27_14245| AS28_06499| CB1_000200046| CD3| CD3 antigen epsilon| CD3 antigen, epsilon polypeptide| CD3E antigen, epsilon polypeptide| CD3E antigen, epsilon polypeptide (TiT3 complex)| CD3e molecule, epsilon (CD3-TCR complex)| CD3epsilon| CD3 epsilon| CD3-epsilon| CD3 epsilon antigen| CD3 Epsilon chain| CD3 epsilon FN18-| CD3 epsilon FN18+| CD3 epsilon subunit| CD3 molecule, epsilon polypeptide| D623_10033560| EGK_06950| H920_07515| IMD18| M91_09739| MDA_GLEAN10018976| N300_14309| N301_05690| N302_11155| N303_13002| N305_04147| N306_12466| N307_03095| N308_13251| N309_03061| N310_08370| N311_09466| N312_10698| N320_05435| N321_07144| N322_04577| N324_04447| N325_01830| N326_10457| N327_10152| N328_09346| N330_06255| N331_09347| N332_12691| N333_08392| N334_04039| N335_10105| N336_04508| N339_06961| N340_06258| PAL_GLEAN10009046| PANDA_017773| t3e| T-cell antigen receptor complex, epsilon subunit of T3| T-cell receptor CD3 epsilon chain| T-cell surface antigen T3/Leu-4 epsilon chain| T-cell surface glycoprotein CD3 epsilon chain| TCRE| TiT3 complex| UY3_09457| Y1Q_017876| Y956_12606| Z169_01684| cd3e

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