The Function of CD38
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Protein names
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Short name:
T10Alternative name(s):
2'-phospho-ADP-ribosyl cyclase2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
ADPRC 1
Cyclic ADP-ribose hydrolase 1
cADPr hydrolase 1
CD antigen CD38
- RS3796863 (CD38) ??
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Top Gene-Substance Interactions
CD38 Interacts with These Diseases
| Disease | Score |
Substances That Increase CD38
| Substances | Interaction | Organism | Category |
Substances That Decrease CD38
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Gene Pathways:
Developmental stage:
Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
Enzyme Regulation:
ATP inhibits the hydrolyzing activity.
Molecular Function:
- Nad+ Nucleosidase Activity
- Transferase Activity
- Phosphorus-Oxygen Lyase Activity
- Nad(P)+ Nucleosidase Activity
Biological Processes:
- Response To Hypoxia
- Signal Transduction
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Female Pregnancy
- Positive Regulation Of Cell Growth
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Insulin Secretion
- Response To Estradiol
- Response To Retinoic Acid
- Response To Progesterone
- Response To Hydroperoxide
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Bone Resorption
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Vasoconstriction
- B Cell Receptor Signaling Pathway
- Long Term Synaptic Depression
- Response To Interleukin-1
- Apoptotic Signaling Pathway
Drug Bank:
- Daratumumab