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  3. CD38

CD38 (CD38 molecule)

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The Function of CD38

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

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Protein names

Recommended name:

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Short name:

T10

Alternative name(s):

2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
ADPRC 1
Cyclic ADP-ribose hydrolase 1
cADPr hydrolase 1
CD antigen CD38

CD38 SNPs

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  1. RS3796863 (CD38) ??

Top Gene-Substance Interactions

CD38 Interacts with These Diseases

Disease Score

Substances That Increase CD38

Substances Interaction Organism Category

Substances That Decrease CD38

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • p53
  • AhR
  • NF-kappaB1
  • PPAR-alpha
  • IRF-1
  • c-Rel

Tissue specificity:

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Gene Pathways:

  • Metabolic pathways
  • Calcium signaling pathway
  • Pancreatic secretion
  • Hematopoietic cell lineage
  • Salivary secretion
  • Nicotinate and nicotinamide metabolism

Developmental stage:

Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

Enzyme Regulation:

ATP inhibits the hydrolyzing activity.

Molecular Function:

  • Nad(P)+ Nucleosidase Activity
  • Nad+ Nucleosidase Activity
  • Phosphorus-Oxygen Lyase Activity
  • Transferase Activity

Biological Processes:

  • Apoptotic Signaling Pathway
  • B Cell Receptor Signaling Pathway
  • Female Pregnancy
  • Long Term Synaptic Depression
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Bone Resorption
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Insulin Secretion
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Vasoconstriction
  • Response To Estradiol
  • Response To Hydroperoxide
  • Response To Hypoxia
  • Response To Interleukin-1
  • Response To Progesterone
  • Response To Retinoic Acid
  • Signal Transduction

Drug Bank:

  • Daratumumab
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| NAD(+) nucleosidase| 2'-phospho-ADP-ribosyl cyclase| 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase| 2'-phospho-cyclic-ADP-ribose transferase| ADPRC1| ADPRC 1| ADP-ribosyl cyclase 1| ADP-ribosyl cyclase CD38| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1| AS27_06309| AS28_05728| cADPr hydrolase 1| CD38/ADP-ribosyl cyclase| CD38 antigen| CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)| CD38 antigen (p45)| CD38H| Cd38-rs1| cluster of differentiation 38| cyclic ADP-ribose hydrolase 1| ecto-nicotinamide adenine dinucleotide glycohydrolase| EGK_15591| H920_12917| hematopoietic antigen CD38| I-19| M91_14420| M959_03018| N300_07350| N301_07570| N302_15047| N305_12922| N306_13313| N307_08049| N308_07619| N309_10617| N310_05601| N311_06897| N312_00897| N320_00393| N321_04560| N322_09591| N324_03333| N325_04187| N326_12281| N327_12947| N328_02446| N329_08333| N331_02174| N332_11633| N333_08780| N334_09462| N335_12892| N336_09826| N339_12633| N340_00551| NIM-R5 antigen| PAL_GLEAN10022688| PANDA_004359| TREES_T100015865| UY3_02817| Y1Q_022575| Y956_10568| Z169_02423| cd38

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