Summary of CD36
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface. It transports fatty acids into cells. It functions to promote the storage in of fatty acids in fat cells, utilization in muscles, and help the absorption of dietary fat and cholesterol in the gut.
CD36 is a receptor for a broad range of molecules, including thrombospondin, fibronectin, collagen or amyloid-beta, oxidized LDL, long-chain fatty acids and bacterial peptides.
When bound to the receptor, these molecules cause inflammatory responses, fatty acid metabolism, taste and dietary fat processing in the intestine.
The receptor is involved in oral fat perception and preferences. In taste receptor cells, it leads to the activation of the gustatory neurons in the nucleus of the solitary tract (by long-chain fatty acids).
Protein names
Recommended name:
Platelet glycoprotein 4Short name:
FATAlternative name(s):
Fatty acid translocaseGlycoprotein IIIb
GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
GPIV
Thrombospondin receptor
CD antigen CD36
- RS10499859 (CD36) ??
- RS11574703 (CD36) ??
- RS13236689 (CD36) ??
- RS1527479 (CD36) ??
- RS1527483 (CD36) ??
- RS2366858 (CD36) ??
- RS3173798 (CD36) ??
- RS3211892 (CD36) ??
- RS3211908 (CD36) ??
- RS3211938 (CD36) ??
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Top Gene-Substance Interactions
CD36 Interacts with These Diseases
| Disease | Score |
Substances That Increase CD36
| Substances | Interaction | Organism | Category |
Substances That Decrease CD36
| Substances | Interaction | Organism | Category |
Advanced Summary
Detection into the tongue of long-chain fatty acids leads to a rapid change in pancreatobiliary secretions.
Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis.
Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects.
As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages.
Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome.
Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
- PPAR-gamma1
- PPAR-gamma2
- PPAR-alpha
- STAT1
- STAT1alpha
- STAT1beta
- USF1
- USF-1
- NF-kappaB1
- NF-kappaB
- PPAR-delta
- PXR
- FOXO1
- LXR
- PPAR-gamma
Gene Pathways:
Molecular Function:
- Low-Density Lipoprotein Receptor Activity
- High-Density Lipoprotein Particle Binding
- Lipid Binding
- Low-Density Lipoprotein Particle Binding
- Transforming Growth Factor Beta Binding
- Thrombospondin Receptor Activity
- Lipoteichoic Acid Receptor Activity
- Lipoprotein Particle Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Cell-Matrix Adhesion
- Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class I, Tap-Dependent
- Platelet Degranulation
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Lipid Metabolic Process
- Receptor-Mediated Endocytosis
- Phagocytosis, Recognition
- Immune Response
- Cell Adhesion
- Cell Surface Receptor Signaling Pathway
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Nitric Oxide Mediated Signal Transduction
- Blood Coagulation
- Positive Regulation Of Macrophage Derived Foam Cell Differentiation
- Positive Regulation Of Cholesterol Storage
- Lipid Storage
- Cgmp-Mediated Signaling
- Positive Regulation Of Blood Coagulation
- Intestinal Cholesterol Absorption
- Cholesterol Transport
- Receptor Internalization
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Tumor Necrosis Factor Production
- Response To Lipid
- Triglyceride Transport
- Plasma Lipoprotein Particle Clearance
- Low-Density Lipoprotein Particle Clearance
- Response To Stilbenoid
- Toll-Like Receptor Tlr6:Tlr2 Signaling Pathway
- Lipoprotein Transport
- Negative Regulation Of Transcription Factor Import Into Nucleus
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Apoptotic Cell Clearance
- Negative Regulation Of Growth Of Symbiont In Host
- Long-Chain Fatty Acid Import
- Interleukin-1 Beta Secretion
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Defense Response To Gram-Positive Bacterium
- Intestinal Absorption
- Sensory Perception Of Taste
- Low-Density Lipoprotein Particle Mediated Signaling
- Positive Regulation Of Phagocytosis, Engulfment
- Positive Regulation Of Macrophage Cytokine Production
- Positive Regulation Of Erk1 And Erk2 Cascade
- Cholesterol Import
- Response To Fatty Acid
- Response To Linoleic Acid
- Cellular Response To Lipopolysaccharide
- Cellular Response To Lipoteichoic Acid
- Cellular Response To Low-Density Lipoprotein Particle Stimulus
- Cellular Response To Hydroperoxide
- Cellular Response To Diacyl Bacterial Lipopeptide
- Positive Regulation Of Nlrp3 Inflammasome Complex Assembly
- Amyloid Fibril Formation
- Regulation Of Removal Of Superoxide Radicals
- Positive Regulation Of Blood Microparticle Formation
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Regulation Of Energy Homeostasis