The Function of CD163
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein names
Recommended name:
Scavenger receptor cysteine-rich type 1 protein M130Alternative name(s):
Hemoglobin scavenger receptorCD antigen CD163
sCD163
- RS7136716 (CD163) ??
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Top Gene-Substance Interactions
Substances That Increase CD163
| Substances | Interaction | Organism | Category |
Substances That Decrease CD163
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Induction:
Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF.
Caution:
It is uncertain whether Met-1 or Met-6 is the initiator.
Molecular Function:
Biological Processes:
Drug Bank:
- Wf10