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  3. CD163

CD163 (CD163 molecule)

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The Function of CD163

After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

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Protein names

Recommended name:

Scavenger receptor cysteine-rich type 1 protein M130

Alternative name(s):

Hemoglobin scavenger receptor
CD antigen CD163
sCD163

CD163 SNPs

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  1. RS7136716 (CD163) ??

Top Gene-Substance Interactions

Substances That Increase CD163

Substances Interaction Organism Category

Substances That Decrease CD163

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Tissue specificity:

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Induction:

Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF.

Caution:

It is uncertain whether Met-1 or Met-6 is the initiator.

Molecular Function:

  • Scavenger Receptor Activity

Biological Processes:

  • Acute-Phase Response
  • Receptor-Mediated Endocytosis

Drug Bank:

  • Wf10
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Antigen WC1.1| AS28_01378| CD163 antigen| CD163v2| CD163v3| D623_10003164| Deleted in malignant brain tumors 1 protein| EGK_03316| H920_16548| hemoglobin scavenger receptor| M130| M91_11253| macrophage-associated antigen| MDA_GLEAN10016011| MM130| N310_07316| N330_07923| N335_08769| SCARI1| Scavenger receptor cysteine-rich type 1 protein M130| TREES_T100002761| cd163

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