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  3. CD14

CD14 (CD14 molecule)

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The Function of CD14

Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).

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Protein names

Recommended name:

Monocyte differentiation antigen CD14

Alternative name(s):

Myeloid cell-specific leucine-rich glycoprotein
CD antigen CD14

CD14 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2569190 (CD14) ??
  2. RS5744455 (CD14) ??

Top Gene-Substance Interactions

CD14 Interacts with These Diseases

Disease Score

Substances That Increase CD14

Substances Interaction Organism Category

Substances That Decrease CD14

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • Max
  • c-Jun
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • c-Rel
  • Pax-5

Tissue specificity:

Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Gene Pathways:

  • Immune System
  • MAPK signaling pathway
  • Regulation of actin cytoskeleton
  • Toll-like receptor signaling pathway
  • Tuberculosis
  • Pathogenic Escherichia coli infection
  • Innate Immune System
  • Amoebiasis
  • Hematopoietic cell lineage
  • Phagosome

Induction:

The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.

Molecular Function:

  • Lipopolysaccharide Binding
  • Lipoteichoic Acid Binding
  • Opsonin Receptor Activity
  • Peptidoglycan Receptor Activity

Biological Processes:

  • Apoptotic Process
  • Apoptotic Signaling Pathway
  • Cell Surface Receptor Signaling Pathway
  • Cellular Response To Diacyl Bacterial Lipopeptide
  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Lipoteichoic Acid
  • Cellular Response To Triacyl Bacterial Lipopeptide
  • I-Kappab Kinase/Nf-Kappab Signaling
  • Inflammatory Response
  • Innate Immune Response
  • Lipopolysaccharide-Mediated Signaling Pathway
  • Myd88-Dependent Toll-Like Receptor Signaling Pathway
  • Myd88-Independent Toll-Like Receptor Signaling Pathway
  • Necroptotic Process
  • Negative Regulation Of Myd88-Independent Toll-Like Receptor Signaling Pathway
  • Phagocytosis
  • Positive Regulation Of Cytokine Secretion
  • Positive Regulation Of Endocytosis
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Tumor Necrosis Factor Production
  • Positive Regulation Of Type I Interferon Production
  • Receptor-Mediated Endocytosis
  • Response To Electrical Stimulus
  • Response To Ethanol
  • Response To Heat
  • Response To Magnesium Ion
  • Response To Tumor Necrosis Factor
  • Toll-Like Receptor 4 Signaling Pathway
  • Toll-Like Receptor Tlr1:Tlr2 Signaling Pathway
  • Toll-Like Receptor Tlr6:Tlr2 Signaling Pathway
  • Trif-Dependent Toll-Like Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_04325| AS28_07064| CD14 antigen| CD14 molecule-like| GW7_12541| I79_018634| lipopolysaccharide receptor| M91_15337| M959_03823| MDA_GLEAN10012432| Monocyte differentiation antigen CD14| monocyte differentiation antigen CD14-like protein| myeloid cell-specific leucine-rich glycoprotein| N300_15118| N303_04345| N308_13583| N309_07333| N310_09099| N311_07798| N312_06675| N321_07052| N322_06469| N324_06718| N327_06020| N331_00213| N336_06517| N341_06698| PAL_GLEAN10016783| PANDA_000368| Toll-like receptor 2| Toll-like receptor 2 type-1| Toll-like receptor 2 type-2| TREES_T100019624| Y956_12288| cd14

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