The Function of CD14
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
Protein names
Recommended name:
Monocyte differentiation antigen CD14Alternative name(s):
Myeloid cell-specific leucine-rich glycoproteinCD antigen CD14
- RS2569190 (CD14) ??
- RS5744455 (CD14) ??
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Top Gene-Substance Interactions
CD14 Interacts with These Diseases
| Disease | Score |
Substances That Increase CD14
| Substances | Interaction | Organism | Category |
Substances That Decrease CD14
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Gene Pathways:
Induction:
The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.
Molecular Function:
- Lipopolysaccharide Binding
- Lipoteichoic Acid Binding
- Opsonin Receptor Activity
- Peptidoglycan Receptor Activity
Biological Processes:
- Apoptotic Process
- Apoptotic Signaling Pathway
- Cell Surface Receptor Signaling Pathway
- Cellular Response To Diacyl Bacterial Lipopeptide
- Cellular Response To Lipopolysaccharide
- Cellular Response To Lipoteichoic Acid
- Cellular Response To Triacyl Bacterial Lipopeptide
- I-Kappab Kinase/Nf-Kappab Signaling
- Inflammatory Response
- Innate Immune Response
- Lipopolysaccharide-Mediated Signaling Pathway
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Myd88-Independent Toll-Like Receptor Signaling Pathway
- Necroptotic Process
- Negative Regulation Of Myd88-Independent Toll-Like Receptor Signaling Pathway
- Phagocytosis
- Positive Regulation Of Cytokine Secretion
- Positive Regulation Of Endocytosis
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Tumor Necrosis Factor Production
- Positive Regulation Of Type I Interferon Production
- Receptor-Mediated Endocytosis
- Response To Electrical Stimulus
- Response To Ethanol
- Response To Heat
- Response To Magnesium Ion
- Response To Tumor Necrosis Factor
- Toll-Like Receptor 4 Signaling Pathway
- Toll-Like Receptor Tlr1:Tlr2 Signaling Pathway
- Toll-Like Receptor Tlr6:Tlr2 Signaling Pathway
- Trif-Dependent Toll-Like Receptor Signaling Pathway