The Function of CD109
Modulates negatively TGFB1 signaling in keratinocytes.
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Protein names
Recommended name:
CD109 antigenAlternative name(s):
150 kDa TGF-beta-1-binding proteinC3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD antigen CD109
- RS9447004 (CD109) ??
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Top Gene-Substance Interactions
Substances That Increase CD109
| Substances | Interaction | Organism | Category |
Substances That Decrease CD109
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.
Molecular Function:
Biological Processes:
- Hair Follicle Development
- Negative Regulation Of Keratinocyte Proliferation
- Negative Regulation Of Protein Phosphorylation
- Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Negative Regulation Of Wound Healing
- Osteoclast Fusion
- Regulation Of Keratinocyte Differentiation