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  2. Genes
  3. CD109

CD109 (CD109 molecule)

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The Function of CD109

Modulates negatively TGFB1 signaling in keratinocytes.

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Protein names

Recommended name:

CD109 antigen

Alternative name(s):

150 kDa TGF-beta-1-binding protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD antigen CD109

CD109 SNPs

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  1. RS9447004 (CD109) ??

Top Gene-Substance Interactions

Substances That Increase CD109

Substances Interaction Organism Category

Substances That Decrease CD109

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • c-Jun
  • Pax-6
  • Fra-1

Tissue specificity:

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.

Molecular Function:

  • Serine-Type Endopeptidase Inhibitor Activity
  • Transforming Growth Factor Beta Binding

Biological Processes:

  • Hair Follicle Development
  • Negative Regulation Of Keratinocyte Proliferation
  • Negative Regulation Of Protein Phosphorylation
  • Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Negative Regulation Of Wound Healing
  • Osteoclast Fusion
  • Regulation Of Keratinocyte Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 150 kDa TGF-beta-1-binding protein| activated T-cell marker CD109| C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7| CB1_000591002| CD109 antigen| CPAMD7| D623_10025111| GARP| Gov platelet alloantigens| GPI-anchored alpha 2 macroglobulin-related protein| H920_01249| M91_08921| MDA_GLEAN10020524| N300_11891| N301_09050| N302_06237| N306_11884| N307_01622| N310_12799| N311_12855| N312_07026| N322_01340| N324_03889| N327_00821| N331_09478| N333_12248| N334_03491| N335_01878| N339_11001| p180| PAL_GLEAN10025243| PANDA_004706| platelet-specific Gov antigen| r150| TREES_T100015464| UY3_14223| Y1Q_007759| cd109

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