The Function of CCR7
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
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Protein names
Recommended name:
C-C chemokine receptor type 7Short name:
BLR2Alternative name(s):
C-C CKR-7CC-CKR-7
CCR-7
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
EBI1
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD antigen CD197
- RS112401631 (CCR7) ??
- RS3136685 (CCR7) ??
- RS7221109 (CCR7) ??
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Top Gene-Substance Interactions
CCR7 Interacts with These Diseases
| Disease | Score |
Substances That Increase CCR7
| Substances | Interaction | Organism | Category |
Substances That Decrease CCR7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Gene Pathways:
Induction:
By Epstein-Barr virus (EBV).
Molecular Function:
- G-Protein Coupled Receptor Activity
- C-C Chemokine Receptor Activity
- Chemokine (C-C Motif) Ligand 19 Binding
- Chemokine (C-C Motif) Ligand 21 Binding
- C-C Motif Chemokine 19 Receptor Activity
- C-C Motif Chemokine 21 Receptor Activity
Biological Processes:
- Establishment Of T Cell Polarity
- Positive Regulation Of Cell-Matrix Adhesion
- Dendritic Cell Chemotaxis
- Myeloid Dendritic Cell Chemotaxis
- Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
- Positive Regulation Of Hypersensitivity
- Positive Regulation Of Humoral Immune Response
- Inflammatory Response
- Immune Response
- G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Actin Filament Polymerization
- Positive Regulation Of Pseudopodium Assembly
- Ruffle Organization
- Response To Lipopolysaccharide
- Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-12 Production
- Response To Prostaglandin E
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
- Negative Thymic T Cell Selection
- Positive Regulation Of Cell Adhesion
- Positive Regulation Of Protein Kinase Activity
- Positive Regulation Of Jnk Cascade
- Homeostasis Of Number Of Cells
- Regulation Of Interleukin-1 Beta Secretion
- Positive Regulation Of T Cell Receptor Signaling Pathway
- Release Of Sequestered Calcium Ion Into Cytosol
- Positive Regulation Of Filopodium Assembly
- Positive Regulation Of Protein Kinase B Signaling
- Positive Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Cytokine Stimulus
- Response To Nitric Oxide
- Interleukin-12 Secretion
- Positive Regulation Of Neutrophil Chemotaxis
- Activation Of Gtpase Activity
- Lymphocyte Migration Into Lymph Node
- Mature Conventional Dendritic Cell Differentiation
- Negative Regulation Of Leukocyte Apoptotic Process
- Positive Regulation Of Cell Motility
- Positive Regulation Of Dendritic Cell Chemotaxis
- Positive Regulation Of Immunological Synapse Formation
- Positive Regulation Of T Cell Costimulation
- Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation
- Regulation Of Dendritic Cell Dendrite Assembly