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  3. CCR7

CCR7 (C-C motif chemokine receptor 7)

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The Function of CCR7

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

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Protein names

Recommended name:

C-C chemokine receptor type 7

Short name:

BLR2

Alternative name(s):

C-C CKR-7
CC-CKR-7
CCR-7
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
EBI1
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD antigen CD197

CCR7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS112401631 (CCR7) ??
  2. RS3136685 (CCR7) ??
  3. RS7221109 (CCR7) ??

Top Gene-Substance Interactions

CCR7 Interacts with These Diseases

Disease Score

Substances That Increase CCR7

Substances Interaction Organism Category

Substances That Decrease CCR7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • STAT3
  • NF-kappaB1
  • STAT5A
  • STAT1
  • STAT1beta
  • STAT1alpha
  • GATA-3

Tissue specificity:

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway

Induction:

By Epstein-Barr virus (EBV).

Molecular Function:

  • C-C Chemokine Receptor Activity
  • C-C Motif Chemokine 19 Receptor Activity
  • C-C Motif Chemokine 21 Receptor Activity
  • Chemokine (C-C Motif) Ligand 19 Binding
  • Chemokine (C-C Motif) Ligand 21 Binding
  • G-Protein Coupled Receptor Activity

Biological Processes:

  • Activation Of Gtpase Activity
  • Cellular Response To Cytokine Stimulus
  • Dendritic Cell Chemotaxis
  • Establishment Of T Cell Polarity
  • G-Protein Coupled Receptor Signaling Pathway
  • Homeostasis Of Number Of Cells
  • Immune Response
  • Inflammatory Response
  • Interleukin-12 Secretion
  • Lymphocyte Migration Into Lymph Node
  • Mature Conventional Dendritic Cell Differentiation
  • Myeloid Dendritic Cell Chemotaxis
  • Negative Regulation Of Leukocyte Apoptotic Process
  • Negative Thymic T Cell Selection
  • Positive Regulation Of Actin Filament Polymerization
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Cell-Matrix Adhesion
  • Positive Regulation Of Cell Motility
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
  • Positive Regulation Of Dendritic Cell Chemotaxis
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Filopodium Assembly
  • Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation
  • Positive Regulation Of Humoral Immune Response
  • Positive Regulation Of Hypersensitivity
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Immunological Synapse Formation
  • Positive Regulation Of Interleukin-12 Production
  • Positive Regulation Of Jnk Cascade
  • Positive Regulation Of Neutrophil Chemotaxis
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
  • Positive Regulation Of Protein Kinase Activity
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Pseudopodium Assembly
  • Positive Regulation Of T Cell Costimulation
  • Positive Regulation Of T Cell Receptor Signaling Pathway
  • Regulation Of Dendritic Cell Dendrite Assembly
  • Regulation Of Interferon-Gamma Production
  • Regulation Of Interleukin-1 Beta Secretion
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Response To Lipopolysaccharide
  • Response To Nitric Oxide
  • Response To Prostaglandin E
  • Ruffle Organization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| chemokine receptor 7| A306_14066| Anapl_12188| BLR2| Bukitt's lymphoma receptor 2| CB1_001119008| CC chemokine receptor 7| C-C chemokine receptor type 7| c-C chemokine receptor type 7-like protein| C-C CKR-7| CC-CKR-7| CCR-7| CD197| CDw197| chemokine (C-C motif) receptor 7| chemokine (C-C) receptor 7| CMKBR7| D623_10030352| EBI1| Ebi1h| EBV-induced G protein-coupled receptor 1| EBV-induced G-protein coupled receptor 1| Epstein-Barr virus induced gene 1| Epstein-Barr virus-induced G-protein coupled receptor 1| H920_19814| lymphocyte-specific G protein-coupled peptide receptor| M91_05305| MIP-3 beta receptor| N307_01190| N320_01799| N340_04505| PAL_GLEAN10019589| PANDA_014410| UY3_09148| Y1Q_023786| zfCCR7| ccr7

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