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  3. CCR4

CCR4 (C-C motif chemokine receptor 4)

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The Function of CCR4

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

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Protein names

Recommended name:

C-C chemokine receptor type 4

Short name:

CCR4

Alternative name(s):

C-C CKR-4
CC-CKR-4
CCR-4
K5-5
CD antigen CD194

CCR4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4868644 (CCR4) ??
  2. RS7648704 (CCR4) ??

Top Gene-Substance Interactions

CCR4 Interacts with These Diseases

Disease Score

Substances That Increase CCR4

Substances Interaction Organism Category

Substances That Decrease CCR4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR

Tissue specificity:

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway

Molecular Function:

  • C-C Chemokine Receptor Activity
  • Chemokine Receptor Activity

Biological Processes:

  • Chemotaxis
  • Homeostasis Of Number Of Cells
  • Immune Response
  • Inflammatory Response
  • Neuron Migration
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Positive Chemotaxis
  • Response To Antibiotic
  • Response To Bacterium
  • Response To Radiation
  • Tolerance Induction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

A306_11556| AS27_10423| AS28_06802| C-C chemokine receptor 4| CC chemokine receptor 4| CC-chemokine receptor 4| C-C chemokine receptor type 4| c-C chemokine receptor type 4-like protein| C-C CKR-4| CC-CKR-4| CCR-4| CCR4 carbon catabolite repression 4-like| Ccrn4l| CD194| chemokine (C-C motif) receptor 4| chemokine (C-C) receptor 4| chemokine receptor 4| chemokine receptor CCR4| CHEMR1| ChemR13| CKR4| CMKBR4| EGK_12176| fusin| GW7_21428| H920_07651| HGCN:14099| K5-5| LESTR| leukocyte-expressed seven-transmembrane-domain receptor| M959_12568| MDA_GLEAN10018226| N300_01490| N301_11972| N303_02214| N306_11425| N307_14218| N308_01761| N309_07812| N310_01907| N312_11869| N320_09877| N321_06896| N322_11080| N325_02058| N327_02091| N328_05378| N329_01471| N330_07311| N331_03401| N332_05376| N334_13954| N335_01406| N336_05804| N339_02850| N340_13149| N341_12360| PAL_GLEAN10012801| PANDA_007661| Sdf1r| TREES_T100003701| Y956_11374| Z169_09962| ccr4

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