The Function of CCR4
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Protein names
Recommended name:
C-C chemokine receptor type 4Short name:
CCR4Alternative name(s):
C-C CKR-4CC-CKR-4
CCR-4
K5-5
CD antigen CD194
- RS4868644 (CCR4) ??
- RS7648704 (CCR4) ??
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Top Gene-Substance Interactions
CCR4 Interacts with These Diseases
| Disease | Score |
Substances That Increase CCR4
| Substances | Interaction | Organism | Category |
Substances That Decrease CCR4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- Neuron Migration
- Tolerance Induction
- Chemotaxis
- Inflammatory Response
- Immune Response
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Response To Radiation
- Response To Bacterium
- Response To Antibiotic
- Homeostasis Of Number Of Cells
- Positive Regulation Of Positive Chemotaxis