The Function of CCNH
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
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Protein names
Recommended name:
Cyclin-HAlternative name(s):
MO15-associated proteinp34
p37
Top Gene-Substance Interactions
CCNH Interacts with These Diseases
| Disease | Score |
Substances That Increase CCNH
| Substances | Interaction | Organism | Category |
Substances That Decrease CCNH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- G1/S Transition Of Mitotic Cell Cycle
- G2/M Transition Of Mitotic Cell Cycle
- Transcription-Coupled Nucleotide-Excision Repair
- Nucleotide-Excision Repair, Preincision Complex Assembly
- Transcription Initiation From Rna Polymerase I Promoter
- Transcription Elongation From Rna Polymerase I Promoter
- Termination Of Rna Polymerase I Transcription
- Transcription From Rna Polymerase Ii Promoter
- Transcription Initiation From Rna Polymerase Ii Promoter
- Transcription Elongation From Rna Polymerase Ii Promoter
- 7-Methylguanosine Mrna Capping
- Protein Phosphorylation
- Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Phosphorylation Of Rna Polymerase Ii C-Terminal Domain