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  3. CCNH

CCNH (Cyclin H)

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The Function of CCNH

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

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Protein names

Recommended name:

Cyclin-H

Alternative name(s):

MO15-associated protein
p34
p37

Top Gene-Substance Interactions

CCNH Interacts with These Diseases

Disease Score

Substances That Increase CCNH

Substances Interaction Organism Category

Substances That Decrease CCNH

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • p53

Gene Pathways:

  • Disease
  • Gene Expression
  • DNA Repair
  • Nucleotide excision repair
  • Transcription
  • Basal transcription factors

Molecular Function:

  • Cyclin-Dependent Protein Serine/Threonine Kinase Regulator Activity

Biological Processes:

  • 7-Methylguanosine Mrna Capping
  • G1/S Transition Of Mitotic Cell Cycle
  • G2/M Transition Of Mitotic Cell Cycle
  • Nucleotide-Excision Repair, Preincision Complex Assembly
  • Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Positive Regulation Of Phosphorylation Of Rna Polymerase Ii C-Terminal Domain
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Phosphorylation
  • Termination Of Rna Polymerase I Transcription
  • Transcription-Coupled Nucleotide-Excision Repair
  • Transcription Elongation From Rna Polymerase Ii Promoter
  • Transcription Elongation From Rna Polymerase I Promoter
  • Transcription From Rna Polymerase Ii Promoter
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Transcription Initiation From Rna Polymerase I Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p34| Anapl_17779| AS27_10260| AS28_09219| AV102684| CAK| CAK complex subunit| CB1_001052019| CDK-activating kinase complex subunit| CycH| cyclin-dependent kinase-activating kinase complex subunit| cyclin-H| cyclin-H-like protein| EGK_16664| GekBS183P| GW7_08020| H920_10802| M91_08220| M959_14422| MO15-associated protein| N301_05746| N302_08948| N303_04822| N306_02520| N307_12180| N308_04869| N310_04791| N311_04968| N312_00378| N320_13299| N321_01562| N322_10691| N327_08359| N328_11155| N329_12804| N330_11008| N334_14282| N335_13171| N336_01790| N339_12266| N340_11562| N341_12695| p37| PAL_GLEAN10024959| PANDA_001484| UY3_01568| Y1Q_013261| Y956_13672| Z169_01816| ccnh

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