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  3. CCL5

CCL5 (C-C motif chemokine ligand 5)

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The Function of CCL5

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

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Protein names

Recommended name:

C-C motif chemokine 5

Alternative name(s):

EoCP
Eosinophil chemotactic cytokine
SIS-delta
Small-inducible cytokine A5
T cell-specific protein P228
TCP228
T-cell-specific protein RANTES
3-68
4-68

CCL5 SNPs

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  1. RS2107538 (CCL5) ??
  2. RS2280788 (CCL5) ??
  3. RS2280789 (CCL5) ??
  4. RS3817655 (CCL5) ??

Top Gene-Substance Interactions

CCL5 Interacts with These Diseases

Disease Score

Substances That Increase CCL5

Substances Interaction Organism Category

Substances That Decrease CCL5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • IRF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • C/EBPbeta
  • AP-1
  • c-Jun
  • c-Rel

Tissue specificity:

Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.

Gene Pathways:

  • Rheumatoid arthritis
  • Chemokine signaling pathway
  • Cytosolic DNA-sensing pathway
  • Chagas disease (American trypanosomiasis)
  • Toll-like receptor signaling pathway
  • NOD-like receptor signaling pathway
  • Prion diseases
  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Epithelial cell signaling in Helicobacter pylori infection

Induction:

By mitogens.

Molecular Function:

  • Phosphatidylinositol Phospholipase C Activity
  • Chemokine Activity
  • Heparin Binding
  • Phospholipase Activator Activity
  • Receptor Signaling Protein Tyrosine Kinase Activator Activity
  • Ccr1 Chemokine Receptor Binding
  • Ccr4 Chemokine Receptor Binding
  • Ccr5 Chemokine Receptor Binding
  • Chemoattractant Activity
  • Chemokine Receptor Binding
  • Protein Homodimerization Activity
  • Protein Self-Association
  • Chemokine Receptor Antagonist Activity

Biological Processes:

  • Mapk Cascade
  • Dendritic Cell Chemotaxis
  • Chronic Inflammatory Response
  • Monocyte Chemotaxis
  • Regulation Of Chronic Inflammatory Response
  • Calcium Ion Transport
  • Cellular Calcium Ion Homeostasis
  • Exocytosis
  • Chemotaxis
  • Inflammatory Response
  • Leukocyte Cell-Cell Adhesion
  • G-Protein Coupled Receptor Signaling Pathway
  • Cell-Cell Signaling
  • Aging
  • Response To Virus
  • Response To Toxic Substance
  • Response To Salt Stress
  • Positive Regulation Of Activation Of Jak2 Kinase Activity
  • Positive Regulation Of Macrophage Chemotaxis
  • Positive Regulation Of T Cell Chemotaxis
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Dibenzo-P-Dioxin Metabolic Process
  • Positive Regulation Of Cell Migration
  • Neutrophil Chemotaxis
  • Positive Regulation Of Cellular Biosynthetic Process
  • Activation Of Phospholipase D Activity
  • Positive Regulation Of Fever Generation
  • Lipopolysaccharide-Mediated Signaling Pathway
  • Response To Insulin
  • Positive Regulation Of Cell-Cell Adhesion Mediated By Integrin
  • Positive Regulation Of Homotypic Cell-Cell Adhesion
  • Positive Regulation Of T Cell Proliferation
  • Neutrophil Activation
  • Positive Regulation Of Phosphorylation
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat Protein
  • Protein Kinase B Signaling
  • Positive Regulation Of Gtpase Activity
  • Cellular Protein Complex Assembly
  • Response To Estrogen
  • Negative Regulation By Host Of Viral Transcription
  • Cellular Response To Fibroblast Growth Factor Stimulus
  • Positive Regulation Of Viral Genome Replication
  • Negative Regulation Of Viral Genome Replication
  • Positive Regulation Of Innate Immune Response
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Osteoclast Differentiation
  • Negative Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Translational Initiation
  • Positive Regulation Of Jak-Stat Cascade
  • Eosinophil Chemotaxis
  • Macrophage Chemotaxis
  • Lymphocyte Chemotaxis
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Epithelial Cell Proliferation
  • Positive Regulation Of Inflammatory Response
  • Regulation Of Insulin Secretion
  • Regulation Of T Cell Activation
  • Protein Tetramerization
  • Response To Glucocorticoid
  • Positive Regulation Of Calcium Ion Transport
  • Positive Regulation Of Mast Cell Chemotaxis
  • Chemokine-Mediated Signaling Pathway
  • Negative Regulation Of T Cell Apoptotic Process
  • Positive Regulation Of T Cell Apoptotic Process
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Response To Cholesterol
  • Cellular Response To Amino Acid Stimulus
  • Cellular Response To Vitamin K
  • Cellular Response To Morphine
  • Cellular Response To Interferon-Gamma
  • Cellular Response To Interleukin-1
  • Cellular Response To Tumor Necrosis Factor
  • Cellular Response To Ethanol
  • Cellular Response To High Density Lipoprotein Particle Stimulus
  • Cellular Response To Organic Cyclic Compound
  • Cellular Response To Alkyl Hydroperoxide
  • Cellular Response To Transforming Growth Factor Beta Stimulus
  • Positive Regulation Of Monocyte Chemotaxis
  • Regulation Of Neuron Death
  • Negative Regulation Of Neuron Death
  • Negative Regulation Of Macrophage Apoptotic Process
  • Positive Regulation Of T Cell Migration
  • Positive Regulation Of Natural Killer Cell Chemotaxis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| beta-chemokine RANTES| CB1_000173007| C-C chemokine ligand 5| C-C motif chemokine 5| chemokine ah294| chemokine CCL5/RANTES| chemokine (C-C motif) ligand 5| chemokine ligand 5| D17S136E| EGK_08420| eoCP| eosinophil chemotactic cytokine| H920_04238| MDA_GLEAN10002796| MuRantes| N301_13883| N306_01875| N308_15268| N310_01967| N311_08331| N320_01196| N322_03123| N324_09277| N325_11468| N326_12740| N328_07655| N330_06981| N331_03081| N332_00722| N333_11082| N334_03168| N336_05700| N339_12856| PANDA_012847| RANTES| regulated upon activation, normally T-expressed, and presumably secreted| regulated upon activation normal T-cell expressed and secreted| scya5| sisd| SIS-delta| small inducible cytokine A5| small-inducible cytokine A5| small inducible cytokine A5 RANTES| small inducible cytokine subfamily A (Cys-Cys), member 5| T-cell specific protein p288| T-cell-specific protein RANTES| TCP228| TREES_T100005524| ccl5

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