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  3. CCL20

CCL20 (C-C motif chemokine ligand 20)

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The Function of CCL20

Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).

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CCL20 SNPs

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  1. RS10175070 (CCL20) ??
  2. RS111781203 (CCL20) ??
  3. RS11691652 (CCL20) ??
  4. RS4973341 (CCL20) ??
  5. RS7556897 (CCL20) ??
  6. RS7591163 (CCL20) ??

Top Gene-Substance Interactions

CCL20 Interacts with These Diseases

Disease Score

Substances That Increase CCL20

Substances Interaction Organism Category

Substances That Decrease CCL20

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • C/EBPalpha
  • Hlf

Tissue specificity:

Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway
  • Rheumatoid arthritis

Induction:

By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.

Molecular Function:

  • Ccr Chemokine Receptor Binding
  • Ccr6 Chemokine Receptor Binding
  • Chemokine Activity

Biological Processes:

  • Calcium-Mediated Signaling Using Intracellular Calcium Source
  • Cell Chemotaxis
  • Cell-Cell Signaling
  • Cellular Response To Interferon-Gamma
  • Cellular Response To Interleukin-1
  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Lipoteichoic Acid
  • Cellular Response To Tumor Necrosis Factor
  • Chemokine-Mediated Signaling Pathway
  • Chemotaxis
  • Defense Response To Bacterium
  • G-Protein Coupled Receptor Signaling Pathway
  • Immune Response
  • Inflammatory Response
  • Lymphocyte Chemotaxis
  • Monocyte Chemotaxis
  • Neutrophil Chemotaxis
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Gtpase Activity
  • Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process
  • Positive Regulation Of Nitric-Oxide Synthase Biosynthetic Process
  • Positive Regulation Of T Cell Migration
  • Signal Transduction
  • T Cell Migration
  • Thymocyte Migration
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_05056| AS27_04125| AS28_03034| beta chemokine exodus-1| beta-chemokine exodus-1| CC chemokine LARC| CC chemokine ligand 20| CC chemokine ST38| C-C motif chemokine 20| chemokine CCL20/MIP-3 alpha| chemokine CCL20/MIP-3ALPHA| chemokine (C-C motif) ligand 20| chemokine ligand 20| ckb4| D623_10013569| Exodus| exodus-1| LARC| liver and activation-regulated chemokine| M91_19880| M959_04766| maacrophage inflammatory protein 3alpha| macrophage inflammatory protein 3 alpha| MDA_GLEAN10026026| mip3a| MIP-3[a]| MIP-3A| MIP-3-alpha| MIP-3ALPHA| N300_10137| N301_14052| N302_05923| N303_02426| N305_11358| N306_07981| N307_05449| N308_00842| N309_02674| N311_08783| N320_08592| N321_11676| N322_13813| N324_07174| N325_09362| N326_10059| N327_10827| N328_08876| N329_09274| N330_01875| N331_05250| N332_06163| N333_01068| N334_04207| N335_11372| N336_11206| N339_07213| N340_02682| N341_08948| PAL_GLEAN10014339| PANDA_014137| SCYA20| small-inducible cytokine A20| small inducible cytokine subfamily A20| small inducible cytokine subfamily A (Cys-Cys), member 20| ST38| TREES_T100015590| Y956_12990| Z169_10308| ccl20

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