The Function of CCL20
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).
- RS10175070 (CCL20) ??
- RS111781203 (CCL20) ??
- RS11691652 (CCL20) ??
- RS4973341 (CCL20) ??
- RS7556897 (CCL20) ??
- RS7591163 (CCL20) ??
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Top Gene-Substance Interactions
CCL20 Interacts with These Diseases
| Disease | Score |
Substances That Increase CCL20
| Substances | Interaction | Organism | Category |
Substances That Decrease CCL20
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Gene Pathways:
Induction:
By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.
Molecular Function:
Biological Processes:
- Calcium-Mediated Signaling Using Intracellular Calcium Source
- Cell Chemotaxis
- Cell-Cell Signaling
- Cellular Response To Interferon-Gamma
- Cellular Response To Interleukin-1
- Cellular Response To Lipopolysaccharide
- Cellular Response To Lipoteichoic Acid
- Cellular Response To Tumor Necrosis Factor
- Chemokine-Mediated Signaling Pathway
- Chemotaxis
- Defense Response To Bacterium
- G-Protein Coupled Receptor Signaling Pathway
- Immune Response
- Inflammatory Response
- Lymphocyte Chemotaxis
- Monocyte Chemotaxis
- Neutrophil Chemotaxis
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process
- Positive Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Positive Regulation Of T Cell Migration
- Signal Transduction
- T Cell Migration
- Thymocyte Migration
- Wound Healing