Summary of CCL20
The CCL20 gene encodes a protein called C-C motif chemokine ligand 20 [R].
This protein helps some types of immune cells move through the body. These cells include dendritic cells, T cells, and B cells. CCL20 is most active in the skin and mucosal surfaces [R, R].
This protein’s effect on the immune system makes it important for disease. CCL20 has been implicated in:
- Cancer [R]
- Rheumatoid arthritis [R]
- Vitiligo [R]
- Multiple sclerosis [R]
- Inflammatory bowel disease (IBD) [R]
- Non-alcoholic fatty liver disease [R]
CCL20 also has antibacterial activity [R].
Protein names
Recommended name:
C-C motif chemokine ligand 20- RS10175070 (CCL20) ??
- RS111781203 (CCL20) ??
- RS11691652 (CCL20) ??
- RS4973341 (CCL20) ??
- RS7556897 (CCL20) ??
- RS7591163 (CCL20) ??
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Top Gene-Substance Interactions
CCL20 Interacts with These Diseases
| Disease | Score |
Substances That Increase CCL20
| Substances | Interaction | Organism | Category |
Substances That Decrease CCL20
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Gene Pathways:
Induction:
By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.
Molecular Function:
Biological Processes:
- Calcium-Mediated Signaling Using Intracellular Calcium Source
- Cell Chemotaxis
- Cell-Cell Signaling
- Cellular Response To Interferon-Gamma
- Cellular Response To Interleukin-1
- Cellular Response To Lipopolysaccharide
- Cellular Response To Lipoteichoic Acid
- Cellular Response To Tumor Necrosis Factor
- Chemokine-Mediated Signaling Pathway
- Chemotaxis
- Defense Response To Bacterium
- G-Protein Coupled Receptor Signaling Pathway
- Immune Response
- Inflammatory Response
- Lymphocyte Chemotaxis
- Monocyte Chemotaxis
- Neutrophil Chemotaxis
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process
- Positive Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Positive Regulation Of T Cell Migration
- Signal Transduction
- T Cell Migration
- Thymocyte Migration
- Wound Healing