• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CCL11

CCL11 (C-C motif chemokine ligand 11)

Loading...

The Function of CCL11

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Eotaxin

Alternative name(s):

C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11

Top Gene-Substance Interactions

CCL11 Interacts with These Diseases

Disease Score

Substances That Increase CCL11

Substances Interaction Organism Category

Substances That Decrease CCL11

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Asthma, susceptibility toHuman immunodeficiency virus type 1, susceptibility to

     From NCBI Gene: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014] From UniProt: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • STAT3
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • GATA-3

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway
  • Asthma

Induction:

By TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.

Molecular Function:

  • Ccr Chemokine Receptor Binding
  • Chemokine Activity

Biological Processes:

  • Actin Filament Organization
  • Branching Involved In Mammary Gland Duct Morphogenesis
  • Cell Adhesion
  • Cellular Calcium Ion Homeostasis
  • Cellular Response To Interferon-Gamma
  • Cellular Response To Interleukin-1
  • Cellular Response To Tumor Necrosis Factor
  • Chemokine-Mediated Signaling Pathway
  • Chemotaxis
  • Chronic Inflammatory Response
  • Cytoskeleton Organization
  • Eosinophil Chemotaxis
  • Erk1 And Erk2 Cascade
  • G-Protein Coupled Receptor Signaling Pathway
  • Inflammatory Response
  • Lymphocyte Chemotaxis
  • Mammary Duct Terminal End Bud Growth
  • Mast Cell Chemotaxis
  • Monocyte Chemotaxis
  • Neutrophil Chemotaxis
  • Positive Regulation Of Actin Filament Polymerization
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Gtpase Activity
  • Positive Regulation Of Inflammatory Response
  • Protein Phosphorylation
  • Regulation Of Cell Shape
  • Response To Interleukin-13
  • Response To Interleukin-4
  • Response To Radiation
  • Response To Virus
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CC chemokine ligand 11| C-C motif chemokine 11| chemokine CCL11/EOTAXIN| chemokine (C-C motif) ligand 11| eosinophil chemotactic protein| eotaxin| eotaxin-1| SCYA11| small chemokine (C-C motif) ligand 11| small inducible cytokine A11| small-inducible cytokine A11| small inducible cytokine subfamily A11| small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)| ccl11

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved