The Function of CCL11
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Protein names
Recommended name:
EotaxinAlternative name(s):
C-C motif chemokine 11Eosinophil chemotactic protein
Small-inducible cytokine A11
Top Gene-Substance Interactions
CCL11 Interacts with These Diseases
| Disease | Score |
Substances That Increase CCL11
| Substances | Interaction | Organism | Category |
Substances That Decrease CCL11
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Asthma, susceptibility toHuman immunodeficiency virus type 1, susceptibility to
From NCBI Gene: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014] From UniProt: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.
Molecular Function:
Biological Processes:
- Actin Filament Organization
- Branching Involved In Mammary Gland Duct Morphogenesis
- Cell Adhesion
- Cellular Calcium Ion Homeostasis
- Cellular Response To Interferon-Gamma
- Cellular Response To Interleukin-1
- Cellular Response To Tumor Necrosis Factor
- Chemokine-Mediated Signaling Pathway
- Chemotaxis
- Chronic Inflammatory Response
- Cytoskeleton Organization
- Eosinophil Chemotaxis
- Erk1 And Erk2 Cascade
- G-Protein Coupled Receptor Signaling Pathway
- Inflammatory Response
- Lymphocyte Chemotaxis
- Mammary Duct Terminal End Bud Growth
- Mast Cell Chemotaxis
- Monocyte Chemotaxis
- Neutrophil Chemotaxis
- Positive Regulation Of Actin Filament Polymerization
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Cell Migration
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of Inflammatory Response
- Protein Phosphorylation
- Regulation Of Cell Shape
- Response To Interleukin-13
- Response To Interleukin-4
- Response To Radiation
- Response To Virus
- Signal Transduction