The Function of CASP3
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
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Protein names
Recommended name:
Caspase-3Short name:
SCA-1Alternative name(s):
CASP-3Apopain
Cysteine protease CPP32
CPP-32
Protein Yama
SREBP cleavage activity 1
- RS1049216 (CASP3) ??
- RS1049253 (CASP3) ??
- RS4647603 (CASP3) ??
- RS6948 (CASP3) ??
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Top Gene-Substance Interactions
CASP3 Interacts with These Diseases
| Disease | Score |
Substances That Increase CASP3
| Substances | Interaction | Organism | Category |
Substances That Decrease CASP3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Gene Pathways:
- Apoptosis
- Tuberculosis
- Toxoplasmosis
- Pathways in cancer
- Epithelial cell signaling in Helicobacter pylori infection
- Parkinson's disease
- Huntington's disease
- Alzheimer's disease
- Viral myocarditis
- Apoptosis
- Colorectal cancer
- Amoebiasis
- p53 signaling pathway
- MAPK signaling pathway
- Signal Transduction
- Amyotrophic lateral sclerosis (ALS)
- Natural killer cell mediated cytotoxicity
- Extracellular matrix organization
Enzyme Regulation:
Inhibited by isatin sulfonamides.
Molecular Function:
- Aspartic-Type Endopeptidase Activity
- Cysteine-Type Endopeptidase Activity
- Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity
- Peptidase Activity
- Cysteine-Type Endopeptidase Activator Activity Involved In Apoptotic Process
- Phospholipase A2 Activator Activity
- Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Cysteine-Type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Processes:
- Response To Hypoxia
- B Cell Homeostasis
- Apoptotic Dna Fragmentation
- Proteolysis
- Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
- Cellular Response To Dna Damage Stimulus
- Heart Development
- Sensory Perception Of Sound
- Learning Or Memory
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
- Response To Uv
- Response To Glucose
- Response To X-Ray
- Regulation Of Macroautophagy
- Protein Processing
- Hippocampus Development
- Neuron Differentiation
- Keratinocyte Differentiation
- Erythrocyte Differentiation
- Platelet Formation
- Negative Regulation Of B Cell Proliferation
- Response To Cobalt Ion
- Response To Estradiol
- Response To Lipopolysaccharide
- Glial Cell Apoptotic Process
- Response To Tumor Necrosis Factor
- Response To Nicotine
- Hippo Signaling
- Wound Healing
- Response To Hydrogen Peroxide
- T Cell Homeostasis
- Negative Regulation Of Apoptotic Process
- Response To Amino Acid
- Positive Regulation Of Neuron Apoptotic Process
- Cell Fate Commitment
- Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Negative Regulation Of Activated T Cell Proliferation
- Response To Antibiotic
- Neurotrophin Trk Receptor Signaling Pathway
- Response To Glucocorticoid
- Neuron Apoptotic Process
- Cellular Response To Organic Cyclic Compound
- Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Execution Phase Of Apoptosis