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  3. CASP10

CASP10 (Caspase 10)

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The Function of CASP10

Isoform C is proteolytically inactive.

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Protein names

Recommended name:

Caspase-10

Short name:

FLICE2

Alternative name(s):

CASP-10
Apoptotic protease Mch-4
FAS-associated death domain protein interleukin-1B-converting enzyme 2
ICE-like apoptotic protease 4

CASP10 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13010627 (CASP10) ??
  2. RS3731714 (CASP10) ??
  3. RS3900115 (CASP10) ??

Top Gene-Substance Interactions

CASP10 Interacts with These Diseases

Disease Score

Substances That Increase CASP10

Substances Interaction Organism Category

Substances That Decrease CASP10

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: autoimmune lymphoproliferative syndromeFrom NCBI Gene: Autoimmune lymphoproliferative syndrome, type 2Malignant lymphoma, non-HodgkinNeoplasm of stomachFrom UniProt: Familial non-Hodgkin lymphoma (NHL): Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. [MIM:605027] Gastric cancer (GASC): A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. [MIM:613659] Autoimmune lymphoproliferative syndrome 2A (ALPS2A): A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. [MIM:603909]

     From NCBI Gene: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8 . Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] From UniProt: Isoform C is proteolytically inactive. Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Gene Pathways:

  • Immune System
  • RIG-I-like receptor signaling pathway
  • Tuberculosis
  • Apoptosis
  • Apoptosis

Molecular Function:

  • Cysteine-Type Endopeptidase Activity
  • Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
  • Death Effector Domain Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Apoptotic Process
  • Apoptotic Signaling Pathway
  • Cell Surface Receptor Signaling Pathway
  • Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Macrophage Differentiation
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Regulation Of Apoptotic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11051| alps2| apoptotic protease MCH-4| AS27_04066| AS28_03247| CASP-10| caspace-10| Caspase-10| caspase 10 apoptosis-related cysteine peptidase| caspase 10, apoptosis-related cysteine peptidase| caspase 10, apoptosis-related cysteine protease| caspase-10 isoform 1 preproprotein| D623_10008611| FADD-like ICE2| FAS-associated death domain protein interleukin-1B-converting enzyme 2| FLICE2| ICE-like apoptotic protease 4| interleukin-1B-converting enzyme 2| mch4| MDA_GLEAN10008509| N300_06703| N301_02458| N303_08510| N306_11813| N307_07765| N311_03452| N331_01647| N333_12382| N334_02397| N335_11907| N336_03331| PAL_GLEAN10026113| PANDA_003925| truncated caspase-10| UY3_18574| xCaspace-10| xCaspase-10| Y956_07523| Z169_07018| casp10

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