Summary of CART
Protein names
Recommended name:
Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CARTShort name:
1-39Alternative name(s):
42-89- RS2239670 (CART) ??
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Top Gene-Substance Interactions
Fixes
Substances That Increase CART
| Substances | Interaction | Organism | Category |
Substances That Decrease CART
| Substances | Interaction | Organism | Category |
Advanced Summary
Cocaine- and amphetamine-regulated transcript (CART) is a natural stimulant that has roles in pleasure, eating, and stress (R).
CART is a neuropeptide that produces similar behavior to cocaine and amphetamines, including increased physical activity and a positive feeling (R).
CART has been shown to suppress food intake, like cocaine and amphetamines (when injected into the 4th ventricle of rats and in nodose ganglia) (R).
Leptin suppresses food intake and increases energy expenditure at least partially by activating CART neurons (R). Mice without CART genes prefer alcohol less (R), which implicates CART in alcoholism. =