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  3. CART

CART (Carcinine transporter)

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Summary of CART

Cocaine- and amphetamine-regulated transcript (CART), is a neuropeptide that produces similar behavior to cocaine and amphetamines (R). It also plays roles in pleasure, eating, and stress and can also suppress food intake (R). 

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Protein names

Recommended name:

Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART

Short name:

1-39

Alternative name(s):

42-89

CART SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2239670 (CART) ??

Top Gene-Substance Interactions

Fixes

CART can help with neurotoxicity.  CART is increased by horny goat weed or icariin (at least in animals with beta amyloid neurotoxicity) (R).

Fixes Advanced

CART is also increased by cocaine and amphetamines (R), but obviously, the risks outweigh the benefits if just used for weight loss.

Substances That Increase CART

Substances Interaction Organism Category

Substances That Decrease CART

Substances Interaction Organism Category

Advanced Summary

Cocaine- and amphetamine-regulated transcript (CART) is a natural stimulant that has roles in pleasure, eating, and stress (R).

CART is a neuropeptide that produces similar behavior to cocaine and amphetamines, including increased physical activity and a positive feeling (R).

CART has been shown to suppress food intake, like cocaine and amphetamines (when injected into the 4th ventricle of rats and in nodose ganglia) (R).

Leptin suppresses food intake and increases energy expenditure at least partially by activating CART neurons (R). Mice without CART genes prefer alcohol less (R), which implicates CART in alcoholism. =

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