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  3. CAPZB

CAPZB (Capping actin protein of muscle Z-line beta subunit)

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The Function of CAPZB

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

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Protein names

Recommended name:

F-actin-capping protein subunit beta

Alternative name(s):

CapZ beta

CAPZB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10799824 (CAPZB) ??
  2. RS10917469 (CAPZB) ??
  3. RS10917477 (CAPZB) ??
  4. RS12045440 (CAPZB) ??
  5. RS12136530 (CAPZB) ??
  6. RS12138950 (CAPZB) ??
  7. RS1472565 (CAPZB) ??
  8. RS7667 (CAPZB) ??

Top Gene-Substance Interactions

CAPZB Interacts with These Diseases

Disease Score

Substances That Increase CAPZB

Substances Interaction Organism Category

Substances That Decrease CAPZB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-alpha
  • C/EBPalpha
  • MEF-2A
  • NF-1
  • c-Myb

Gene Pathways:

  • Hemostasis

Molecular Function:

  • Actin Binding
  • Actin Filament Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion

Biological Processes:

  • Actin Cytoskeleton Organization
  • Barbed-End Actin Filament Capping
  • Blood Coagulation
  • Cytoskeleton Organization
  • Movement Of Cell Or Subcellular Component
  • Negative Regulation Of Filopodium Assembly
  • Regulation Of Cell Morphogenesis
  • Regulation Of Lamellipodium Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| capZ 36/32| A306_07050| actin-capping protein Z beta subunit-like| actin-capping protein Z (cap-Z) beta subunit| AS27_12932| AS28_08783| beta-actinin II| beta-actinin subunit II| CAPB| cappb| Cappb1| capping protein (actin filament) muscle Z-line, beta| capping protein beta 1| capping protein muscle Z-line, beta| CAPZ| capZ B1 and B2| capZ beta| CapZ-beta| CB1_001086042| CPB1| CPB2| CPbeat2| CPbeta1| CP beta1| CPbeta2| D623_10009029| EH28_20704| F-actin capping protein beta subunit| F-actin-capping protein subunit beta| F-actin capping protein subunit beta 1| F-actin-capping protein subunit beta isoforms 1 and 2| H920_19467| I79_014432| M959_05575| MDA_GLEAN10024278| N300_06010| N301_15789| N302_12218| N303_01364| N305_05186| N306_04734| N307_14923| N308_13756| N310_03537| N311_03684| N312_01880| N320_08454| N321_05003| N322_04547| N324_08856| N325_01148| N326_03188| N327_08763| N328_08204| N329_08300| N330_05255| N331_06197| N332_05001| N333_06487| N334_06321| N335_08936| N336_00393| N339_11616| N340_07904| N341_03428| PAL_GLEAN10015227| PANDA_003704| putative actin-capping protein Z beta subunit variant 1| uncharacterized protein LOC100181273| Y1Q_014765| Y956_03114| Z169_14467| capzb

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