The Function of CAPN2
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508).
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Protein names
Recommended name:
Calpain-2 catalytic subunitShort name:
CANP 2Alternative name(s):
Calcium-activated neutral proteinase 2Calpain M-type
Calpain large polypeptide L2
Calpain-2 large subunit
Millimolar-calpain
M-calpain
- RS140084787 (CAPN2) ??
- RS7539624 (CAPN2) ??
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Top Gene-Substance Interactions
Substances That Increase CAPN2
| Substances | Interaction | Organism | Category |
Substances That Decrease CAPN2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Enzyme Regulation:
Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
Cofactor:
Binds 7 Ca(2+) ions.
Molecular Function:
- Calcium-Dependent Cysteine-Type Endopeptidase Activity
- Calcium Ion Binding
- Cytoskeletal Protein Binding
- Cysteine-Type Peptidase Activity
Biological Processes:
- Response To Hypoxia
- Blastocyst Development
- Proteolysis
- Myoblast Fusion
- Protein Autoprocessing
- Extracellular Matrix Disassembly
- Regulation Of Cytoskeleton Organization
- Proteolysis Involved In Cellular Protein Catabolic Process
- Cellular Response To Amino Acid Stimulus