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  3. CAPN2

CAPN2 (Calpain 2)

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The Function of CAPN2

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508).

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Protein names

Recommended name:

Calpain-2 catalytic subunit

Short name:

CANP 2

Alternative name(s):

Calcium-activated neutral proteinase 2
Calpain M-type
Calpain large polypeptide L2
Calpain-2 large subunit
Millimolar-calpain
M-calpain

CAPN2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS140084787 (CAPN2) ??
  2. RS7539624 (CAPN2) ??

Top Gene-Substance Interactions

Substances That Increase CAPN2

Substances Interaction Organism Category

Substances That Decrease CAPN2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Ubiquitous.

Gene Pathways:

  • Alzheimer's disease
  • Apoptosis
  • Protein processing in endoplasmic reticulum

Enzyme Regulation:

Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.

Cofactor:

Binds 7 Ca(2+) ions.

Molecular Function:

  • Calcium-Dependent Cysteine-Type Endopeptidase Activity
  • Calcium Ion Binding
  • Cysteine-Type Peptidase Activity
  • Cytoskeletal Protein Binding

Biological Processes:

  • Blastocyst Development
  • Cellular Response To Amino Acid Stimulus
  • Extracellular Matrix Disassembly
  • Myoblast Fusion
  • Protein Autoprocessing
  • Proteolysis
  • Proteolysis Involved In Cellular Protein Catabolic Process
  • Regulation Of Cytoskeleton Organization
  • Response To Hypoxia
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 80 kDa M-calpain subunit| A306_00326| AS28_00153| calcium-activated neutral proteinase 2| CALP80| calpain 2 catalytic subunit| calpain-2 catalytic subunit| calpain 2, large [catalytic] subunit| calpain 2, large subunit| Calpain-2 large subunit| calpain 2, (m/II) large subunit| calpain II| calpain, large polypeptide L2| calpain M-type| CANP2| CANP 2| CANPL2| CANPml| Capa2| Capa-2| CB1_001073047| cysteine proteinase| H920_13137| I79_000054| M91_07377| M959_04518| m-calpain| m-calpain 80 kDa large subunit| m-calpain large subunit| m-calpin| mCANP| mCL| Millimolar-calpain| N305_12758| N308_04653| N309_03706| N312_02727| N320_07576| N322_04383| N324_10874| N325_03111| N328_02485| N331_05599| PANDA_011412| UY3_18483| Y1Q_027049| capn2

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