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CAPN10 (Calpain 10)

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The Function of CAPN10

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

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Protein names

Recommended name:

Calpain-10

Short name:

CANP 10

Alternative name(s):

Calcium-activated neutral proteinase 10

CAPN10 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2975766 (CAPN10) ??
  2. RS3792267 (CAPN10) ??
  3. RS5030952 (CAPN10) ??

Top Gene-Substance Interactions

Substances That Increase CAPN10

Substances Interaction Organism Category

Substances That Decrease CAPN10

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Diabetes mellitus, noninsulin-dependent, 1From UniProt: Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin . Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [MIM:601283]

     From NCBI Gene: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010] From UniProt: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.

Molecular Function:

  • Calcium-Dependent Cysteine-Type Endopeptidase Activity
  • Cytoskeletal Protein Binding
  • Snare Binding

Biological Processes:

  • Actin Cytoskeleton Reorganization
  • Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
  • Cellular Response To Insulin Stimulus
  • Positive Regulation Of Glucose Import
  • Positive Regulation Of Insulin Secretion
  • Positive Regulation Of Intracellular Transport
  • Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
  • Proteolysis
  • Type B Pancreatic Cell Apoptotic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| A306_05811| AS27_10224| AS28_11316| calcium-activated neutral proteinase 10| Calpain-10| calpain-10-like| calpain 8| calpain-like protease CAPN10| CANP10| CANP 10| Capn8| CB1_000213005| H920_16048| I79_005299| M959_04606| MDA_GLEAN10026146| N300_13377| N301_05126| N302_03763| N303_10275| N305_01864| N306_03984| N307_05253| N308_13896| N310_02874| N311_10720| N312_11086| N320_00475| N321_00922| N322_09024| N324_03008| N325_07138| N326_06761| N327_10159| N328_10619| N330_07564| N331_09640| N332_00627| N333_05492| N334_05671| N335_03959| N336_06399| N339_10037| N340_13085| N341_11256| NIDDM1| PAL_GLEAN10006453| PANDA_012305| TREES_T100020674| UY3_15409| Y1Q_013774| Y956_07142| Z169_03250| capn10

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