Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     From NCBI Gene: Diabetes mellitus, noninsulin-dependent, 1From UniProt: Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin . Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [MIM:601283]

     From NCBI Gene: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010] From UniProt: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• PPAR-gamma1
• PPAR-gamma2
• STAT3
• HNF-4alpha1
• HNF-4alpha2

Tissue specificity:

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.

Molecular Function:

• Snare Binding
• Calcium-Dependent Cysteine-Type Endopeptidase Activity
• Cytoskeletal Protein Binding

Biological Processes:

• Proteolysis
• Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
• Actin Cytoskeleton Reorganization
• Positive Regulation Of Insulin Secretion
• Positive Regulation Of Intracellular Transport
• Cellular Response To Insulin Stimulus
• Positive Regulation Of Glucose Import
• Type B Pancreatic Cell Apoptotic Process
• Positive Regulation Of Type B Pancreatic Cell Apoptotic Process

*synonyms