The Function of CANX
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
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Protein names
Recommended name:
CalnexinAlternative name(s):
IP90Major histocompatibility complex class I antigen-binding protein p88
p90
- RS6893300 (CANX) ??
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Top Gene-Substance Interactions
CANX Interacts with These Diseases
| Disease | Score |
Substances That Increase CANX
| Substances | Interaction | Organism | Category |
Substances That Decrease CANX
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Aging
- Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii
- Antigen Processing And Presentation Of Peptide Antigen Via Mhc Class I
- Chaperone-Mediated Protein Folding
- Clathrin-Dependent Endocytosis
- Protein Folding
- Protein Folding In Endoplasmic Reticulum
- Protein Secretion
- Synaptic Vesicle Endocytosis
Drug Bank:
- Antihemophilic Factor (Recombinant)
- Tenecteplase