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  3. CANX

CANX (Calnexin)

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The Function of CANX

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

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Protein names

Recommended name:

Calnexin

Alternative name(s):

IP90
Major histocompatibility complex class I antigen-binding protein p88
p90

CANX SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6893300 (CANX) ??

Top Gene-Substance Interactions

CANX Interacts with These Diseases

Disease Score

Substances That Increase CANX

Substances Interaction Organism Category

Substances That Decrease CANX

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CUTL1
  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • NF-kappaB1
  • C/EBPbeta
  • c-Fos
  • p300

Gene Pathways:

  • Immune System
  • Metabolism of proteins
  • Antigen processing and presentation
  • Phagosome
  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Calcium Ion Binding
  • Carbohydrate Binding
  • Glycoprotein Binding
  • Poly(A) Rna Binding

Biological Processes:

  • Aging
  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii
  • Antigen Processing And Presentation Of Peptide Antigen Via Mhc Class I
  • Chaperone-Mediated Protein Folding
  • Clathrin-Dependent Endocytosis
  • Protein Folding
  • Protein Folding In Endoplasmic Reticulum
  • Protein Secretion
  • Synaptic Vesicle Endocytosis

Drug Bank:

  • Antihemophilic Factor (Recombinant)
  • Tenecteplase
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14554| Anapl_11423| AS27_12029| AS28_08153| calmegin| calnexin-like protein| canx-a| canx-b| clgn| clnx| CNX| D11Ertd153e| D623_10016186| EMEP| H920_05183| IP90| M91_07673| M959_09620| major histocompatibility complex class I antigen-binding protein p88| N300_10602| N301_12163| N302_05227| N303_03200| N305_02881| N306_11949| N308_14889| N309_06221| N310_11081| N312_03002| N320_09784| N321_00223| N325_00120| N326_01446| N328_07214| N329_02923| N330_06008| N332_09193| N333_09395| N336_10209| N339_06922| N341_05113| P90| PAL_GLEAN10016996| PANDA_010027| PP90| UY3_18227| Y1Q_029003| canx

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