The Function of CALM1
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
- RS5871 (CALM1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CALM1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CALM1
| Substances | Interaction | Organism | Category |
Substances That Decrease CALM1
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Ventricular tachycardia, catecholaminergic polymorphic, 4Long QT syndrome 14From UniProt: Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4): An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. [MIM:614916] Long QT syndrome 14 (LQT14): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [MIM:616247] Long QT syndrome 15 (LQT15): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [MIM:616249]
From NCBI Gene: This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] From UniProt: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Metabolism
- Disease
- Immune System
- Signal Transduction
- Melanogenesis
- Calcium signaling pathway
- Hemostasis
- Tuberculosis
- Neurotrophin signaling pathway
- Vascular smooth muscle contraction
- Alzheimer's disease
- Glioma
- Insulin signaling pathway
- Phosphatidylinositol signaling system
- Gastric acid secretion
- Membrane Trafficking
- Neuronal System
- Olfactory transduction
- Oocyte meiosis
- GnRH signaling pathway
- Salivary secretion
- Muscle contraction
- Translocation of Glut4 to the Plasma Membrane
- Long-term potentiation
- Organelle biogenesis and maintenance
- Phototransduction
Molecular Function:
- Calcium Ion Binding
- Inositol-1,4,5-Trisphosphate 3-Kinase Activity
- Ion Channel Binding
- Ligand-Gated Ion Channel Activity
- N-Terminal Myristoylation Domain Binding
- Nitric-Oxide Synthase Regulator Activity
- Phospholipase Binding
- Protein Domain Specific Binding
- Protein Kinase Binding
- Protein Phosphatase Activator Activity
- Protein Serine/Threonine Kinase Activator Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Thioesterase Binding
- Titin Binding
Biological Processes:
- Activation Of Adenylate Cyclase Activity
- Detection Of Calcium Ion
- Fc-Epsilon Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway
- G2/M Transition Of Mitotic Cell Cycle
- Glycogen Catabolic Process
- Inositol Phosphate Metabolic Process
- Mapk Cascade
- Muscle Contraction
- Negative Regulation Of Peptidyl-Threonine Phosphorylation
- Negative Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Platelet Degranulation
- Positive Regulation Of Cyclic Nucleotide Metabolic Process
- Positive Regulation Of Cyclic-Nucleotide Phosphodiesterase Activity
- Positive Regulation Of Dna Binding
- Positive Regulation Of Nitric-Oxide Synthase Activity
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Positive Regulation Of Phosphoprotein Phosphatase Activity
- Positive Regulation Of Protein Autophosphorylation
- Positive Regulation Of Protein Dephosphorylation
- Positive Regulation Of Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Regulation Of Cardiac Muscle Contraction
- Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
- Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
- Regulation Of Cytokinesis
- Regulation Of Heart Rate
- Regulation Of High Voltage-Gated Calcium Channel Activity
- Regulation Of Nitric-Oxide Synthase Activity
- Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
- Regulation Of Rhodopsin Mediated Signaling Pathway
- Response To Amphetamine
- Response To Calcium Ion
- Response To Corticosterone
- Substantia Nigra Development
- Wnt Signaling Pathway, Calcium Modulating Pathway
Drug Bank:
- Cinchocaine
- Bepridil
- Felodipine
- Flunarizine
- Fluphenazine
- Isoflurane
- Loperamide
- Nicardipine
- Nifedipine
- Phenoxybenzamine
- Pimozide
- Promethazine
- Trifluoperazine
- Aprindine
- Chlorpromazine
- Melatonin
- Perphenazine