The Function of CALM1
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
- RS5871 (CALM1) ??
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Top Gene-Substance Interactions
CALM1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CALM1
| Substances | Interaction | Organism | Category |
Substances That Decrease CALM1
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Ventricular tachycardia, catecholaminergic polymorphic, 4Long QT syndrome 14From UniProt: Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4): An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. [MIM:614916] Long QT syndrome 14 (LQT14): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [MIM:616247] Long QT syndrome 15 (LQT15): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [MIM:616249]
From NCBI Gene: This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] From UniProt: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Metabolism
- Disease
- Immune System
- Signal Transduction
- Melanogenesis
- Calcium signaling pathway
- Hemostasis
- Tuberculosis
- Neurotrophin signaling pathway
- Vascular smooth muscle contraction
- Alzheimer's disease
- Glioma
- Insulin signaling pathway
- Phosphatidylinositol signaling system
- Gastric acid secretion
- Membrane Trafficking
- Neuronal System
- Olfactory transduction
- Oocyte meiosis
- GnRH signaling pathway
- Salivary secretion
- Muscle contraction
- Translocation of Glut4 to the Plasma Membrane
- Long-term potentiation
- Organelle biogenesis and maintenance
- Phototransduction
Molecular Function:
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Calcium Ion Binding
- Inositol-1,4,5-Trisphosphate 3-Kinase Activity
- Ligand-Gated Ion Channel Activity
- Protein Kinase Binding
- Protein Domain Specific Binding
- Nitric-Oxide Synthase Regulator Activity
- Titin Binding
- Thioesterase Binding
- N-Terminal Myristoylation Domain Binding
- Phospholipase Binding
- Protein Serine/Threonine Kinase Activator Activity
- Ion Channel Binding
- Protein Phosphatase Activator Activity
Biological Processes:
- G2/M Transition Of Mitotic Cell Cycle
- Mapk Cascade
- Response To Amphetamine
- Regulation Of Heart Rate
- Platelet Degranulation
- Detection Of Calcium Ion
- Glycogen Catabolic Process
- Muscle Contraction
- G-Protein Coupled Receptor Signaling Pathway
- Activation Of Adenylate Cyclase Activity
- Wnt Signaling Pathway, Calcium Modulating Pathway
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Negative Regulation Of Peptidyl-Threonine Phosphorylation
- Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
- Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
- Substantia Nigra Development
- Regulation Of Rhodopsin Mediated Signaling Pathway
- Positive Regulation Of Cyclic Nucleotide Metabolic Process
- Positive Regulation Of Protein Autophosphorylation
- Regulation Of Cytokinesis
- Positive Regulation Of Phosphoprotein Phosphatase Activity
- Positive Regulation Of Protein Dephosphorylation
- Fc-Epsilon Receptor Signaling Pathway
- Positive Regulation Of Dna Binding
- Inositol Phosphate Metabolic Process
- Regulation Of Nitric-Oxide Synthase Activity
- Positive Regulation Of Nitric-Oxide Synthase Activity
- Positive Regulation Of Cyclic-Nucleotide Phosphodiesterase Activity
- Response To Corticosterone
- Response To Calcium Ion
- Regulation Of Cardiac Muscle Contraction
- Negative Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Positive Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Positive Regulation Of Protein Serine/Threonine Kinase Activity
- Regulation Of High Voltage-Gated Calcium Channel Activity
- Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Drug Bank:
- Cinchocaine
- Bepridil
- Felodipine
- Flunarizine
- Fluphenazine
- Isoflurane
- Loperamide
- Nicardipine
- Nifedipine
- Phenoxybenzamine
- Pimozide
- Promethazine
- Trifluoperazine
- Aprindine
- Chlorpromazine
- Melatonin
- Perphenazine