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  3. CALD1

CALD1 (Caldesmon 1)

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The Function of CALD1

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration.

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Protein names

Recommended name:

Caldesmon

Short name:

CDM

CALD1 SNPs

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  1. RS17169635 (CALD1) ??

Top Gene-Substance Interactions

CALD1 Interacts with These Diseases

Disease Score

Substances That Increase CALD1

Substances Interaction Organism Category

Substances That Decrease CALD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • GR
  • GR-alpha
  • GR-beta
  • Nkx2-2
  • STAT1
  • Cdc5
  • HNF-3beta

Tissue specificity:

High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

Gene Pathways:

  • Vascular smooth muscle contraction
  • Muscle contraction

Molecular Function:

  • Actin Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Calmodulin Binding
  • Tropomyosin Binding

Biological Processes:

  • Movement Of Cell Or Subcellular Component
  • Muscle Contraction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| LCAD| Cytosolic carboxypeptidase 3| A306_10379| Anapl_05591| AS27_06209| AS28_09061| AV071549| CaD| Caldesmon| caldesmon 1b| Caldesmon, smooth muscle| calreticulin| CDM| D623_10009059| EGK_14156| HCAD| H-CAD| h-caldesmon| l-Cad| l-caldesmon| M91_03893| M959_01500| MDA_GLEAN10011588| N300_06640| N301_16186| N303_11582| N306_14668| N307_01853| N308_00346| N309_01883| N310_04619| N312_11487| N320_05517| N321_13598| N322_05631| N324_06996| N325_04240| N326_11268| N329_10236| N330_05925| N331_09537| N332_11197| N333_07872| N335_03989| N339_04568| N341_10519| NAG22| Non-muscle caldesmon| PAL_GLEAN10019110| PANDA_017338| smooth muscle caldesmon| testis secretory sperm-binding protein Li 227n| UY3_07777| Y1Q_006655| Y956_08048| cald1

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