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  3. CA3

CA3 (Carbonic anhydrase 3)

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The Function of CA3

Reversible hydration of carbon dioxide.

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Protein names

Recommended name:

Carbonic anhydrase 3

Short name:

CA-III

Alternative name(s):

Carbonate dehydratase III
Carbonic anhydrase III

Top Gene-Substance Interactions

CA3 Interacts with These Diseases

Disease Score

Substances That Increase CA3

Substances Interaction Organism Category

Substances That Decrease CA3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • AhR
  • XBP-1
  • E2F-1

Tissue specificity:

Muscle specific.

Gene Pathways:

  • Metabolism
  • Nitrogen metabolism

Developmental stage:

At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.

Enzyme Regulation:

Activated by proton donors such as imidazole and the dipeptide histidylhistidine. Inhibited by coumarins and sulfonamide derivatives such as acetazolamide.

Molecular Function:

  • Carbonate Dehydratase Activity
  • Nickel Cation Binding
  • Phosphatase Activity
  • Zinc Ion Binding

Biological Processes:

  • Bicarbonate Transport
  • One-Carbon Metabolic Process
  • Response To Ethanol
  • Response To Oxidative Stress

Drug Bank:

  • Zonisamide
  • Acetazolamide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| carbonic anhydrase III| CAIII| CA-III| Car3| carbonate dehydratase III| carbonic anhydrase III, muscle specific| D623_10016729| epididymis secretory sperm binding protein Li 167mP| GW7_14400| HEL-S-167mP| I79_004474| M91_17668| N308_11825| N311_12142| N312_05269| N320_08412| N324_10999| N326_08321| N327_05194| N333_09637| N335_11715| PAL_GLEAN10019434| PANDA_005083| ca3

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