The Function of C5AR1
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
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Protein names
Recommended name:
C5a anaphylatoxin chemotactic receptor 1Alternative name(s):
C5a anaphylatoxin chemotactic receptorC5a-R
C5aR
CD antigen CD88
- RS7254232 (C5AR1) ??
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Top Gene-Substance Interactions
C5AR1 Interacts with These Diseases
| Disease | Score |
Substances That Increase C5AR1
| Substances | Interaction | Organism | Category |
Substances That Decrease C5AR1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Activation Of Mapk Activity
- Activation Of Phospholipase C Activity
- Animal Organ Regeneration
- Apoptotic Process
- Cell Chemotaxis
- Cell Proliferation In Hindbrain
- Cellular Defense Response
- Chemotaxis
- Defense Response To Gram-Positive Bacterium
- Immune Response
- Inflammatory Response
- Leukocyte Migration
- Mrna Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Neuron Apoptotic Process
- Neutrophil Chemotaxis
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Macrophage Chemotaxis
- Positive Regulation Of Neutrophil Chemotaxis
- Positive Regulation Of Vascular Endothelial Growth Factor Production
- Regulation Of Complement Activation
- Response To Lipopolysaccharide
- Response To Peptidoglycan
- Sensory Perception Of Chemical Stimulus
- Signal Transduction