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  3. C5AR1

C5AR1 (Complement C5a receptor 1)

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The Function of C5AR1

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

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Protein names

Recommended name:

C5a anaphylatoxin chemotactic receptor 1

Alternative name(s):

C5a anaphylatoxin chemotactic receptor
C5a-R
C5aR
CD antigen CD88

C5AR1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7254232 (C5AR1) ??

Top Gene-Substance Interactions

C5AR1 Interacts with These Diseases

Disease Score

Substances That Increase C5AR1

Substances Interaction Organism Category

Substances That Decrease C5AR1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • AhR
  • deltaCREB
  • NF-kappaB1
  • GATA-3

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Complement and coagulation cascades
  • Staphylococcus aureus infection

Molecular Function:

  • Complement Component C5a Receptor Activity
  • G-Protein Coupled Receptor Activity

Biological Processes:

  • Activation Of Mapk Activity
  • Activation Of Phospholipase C Activity
  • Animal Organ Regeneration
  • Apoptotic Process
  • Cell Chemotaxis
  • Cell Proliferation In Hindbrain
  • Cellular Defense Response
  • Chemotaxis
  • Defense Response To Gram-Positive Bacterium
  • Immune Response
  • Inflammatory Response
  • Leukocyte Migration
  • Mrna Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Neuron Apoptotic Process
  • Neutrophil Chemotaxis
  • Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Epithelial Cell Proliferation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Macrophage Chemotaxis
  • Positive Regulation Of Neutrophil Chemotaxis
  • Positive Regulation Of Vascular Endothelial Growth Factor Production
  • Regulation Of Complement Activation
  • Response To Lipopolysaccharide
  • Response To Peptidoglycan
  • Sensory Perception Of Chemical Stimulus
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04878| anaphylatoxin C5a receptor| C5A| C5a anaphylatoxin chemotactic receptor| C5a anaphylatoxin chemotactic receptor 1| C5a anaphylatoxin receptor| C5a ligand| C5a-R| C5AR| C5a receptor| C5r1| CB1_000412009| Cd88| complement C5a receptor| complement component 5a receptor 1| complement component 5 receptor 1| complement component 5, receptor 1| complement component 5 receptor 1 (C5a ligand)| D7Msu1| GPR77| G protein-coupled receptor 77| GW7_18134| M91_02205| N329_05813| PAL_GLEAN10004091| PANDA_012166| TREES_T100011541| c5ar1

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