Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     Covered on Genetics Home Reference: rheumatoid arthritisFrom NCBI Gene: Eculizumab, poor response toLeiner diseaseFrom UniProt: Complement component 5 deficiency (C5D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. [MIM:609536] An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele.

     From NCBI Gene: This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015] From UniProt: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• PPAR-gamma1
• PPAR-gamma2
• GR
• GR-alpha
• GR-beta
• Sp1

Molecular Function:

• Chemokine Activity
• Endopeptidase Inhibitor Activity
• Receptor Binding

Biological Processes:

• Activation Of Mapk Activity
• Cell Surface Receptor Signaling Pathway
• Chemotaxis
• Complement Activation
• Complement Activation, Alternative Pathway
• Complement Activation, Classical Pathway
• Cytolysis
• G-Protein Coupled Receptor Signaling Pathway
• Inflammatory Response
• In Utero Embryonic Development
• Negative Regulation Of Macrophage Chemotaxis
• Positive Regulation Of Angiogenesis
• Positive Regulation Of Chemokine Secretion
• Positive Regulation Of Vascular Endothelial Growth Factor Production
• Regulation Of Complement Activation
• Response To Stress
• Mitophagy In Response To Mitochondrial Depolarization

Drug Bank:

• Eculizumab
• Intravenous Immunoglobulin

*synonyms