The Function of C1QA
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Protein names
Recommended name:
Complement C1q subcomponent subunit A- RS292001 (C1QA) ??
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Top Gene-Substance Interactions
C1QA Interacts with These Diseases
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Substances That Increase C1QA
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Substances That Decrease C1QA
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Advanced Summary
From NCBI Gene: C1q deficiencyFrom UniProt: Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [MIM:613652]
From NCBI Gene: This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008] From UniProt: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell-Cell Signaling
- Complement Activation
- Complement Activation, Classical Pathway
- Innate Immune Response
- Response To Iron Ion
Drug Bank:
- Abciximab
- Adalimumab
- Alefacept
- Alemtuzumab
- Basiliximab
- Bevacizumab
- Cetuximab
- Daclizumab
- Efalizumab
- Etanercept
- Gemtuzumab Ozogamicin
- Ibritumomab
- Muromonab
- Natalizumab
- Palivizumab
- Tositumomab
- Trastuzumab
- Rituximab