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  3. C11ORF73

C11ORF73 (Hikeshi, heat shock protein nuclear import factor)

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The Function of C11ORF73

Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.

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Protein names

Recommended name:

Protein Hikeshi

C11ORF73 SNPs

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  1. RS6592284 (C11ORF73) ??

C11ORF73 Interacts with These Diseases

Disease Score

Advanced Summary

     From NCBI Gene: Leukodystrophy, hypomyelinating, 13

     From NCBI Gene: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016] From UniProt: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • HSF2
  • Nkx3-1 v1
  • Nkx3-1

Induction:

Following heat-shock treatment.

Molecular Function:

  • Hsp70 Protein Binding
  • Protein Transporter Activity

Biological Processes:

  • Cellular Response To Heat
  • Protein Import Into Nucleus
  • Protein Transport
  • Regulation Of Cellular Response To Heat
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| protein Hikeshi| c11orf73

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