The Function of BTC
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
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0 users want it decreased
Protein names
Recommended name:
Probetacellulin [Cleaved into: BetacellulinShort name:
BTC- RS10034692 (BTC) ??
- RS10518128 (BTC) ??
- RS12642133 (BTC) ??
- RS62314947 (BTC) ??
- RS6854845 (BTC) ??
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Top Gene-Substance Interactions
Substances That Increase BTC
| Substances | Interaction | Organism | Category |
Substances That Decrease BTC
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Gene Pathways:
Molecular Function:
- Epidermal Growth Factor Receptor Binding
- Growth Factor Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
Biological Processes:
- Epidermal Growth Factor Receptor Signaling Pathway
- Erbb2 Signaling Pathway
- Mapk Cascade
- Negative Regulation Of Apoptotic Process
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Cell Differentiation
- Positive Regulation Of Cell Division
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Fibroblast Proliferation
- Positive Regulation Of Mitotic Nuclear Division
- Positive Regulation Of Urine Volume
- Regulation Of Cell Motility
- Regulation Of Phosphatidylinositol 3-Kinase Signaling