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BTC (Betacellulin)

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The Function of BTC

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Probetacellulin [Cleaved into: Betacellulin

Short name:

BTC

BTC SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10034692 (BTC) ??
  2. RS10518128 (BTC) ??
  3. RS12642133 (BTC) ??
  4. RS62314947 (BTC) ??
  5. RS6854845 (BTC) ??

Top Gene-Substance Interactions

Substances That Increase BTC

Substances Interaction Organism Category

Substances That Decrease BTC

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • FOXO4
  • FOXO1a
  • FOXO1

Tissue specificity:

Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction

Molecular Function:

  • Epidermal Growth Factor Receptor Binding
  • Growth Factor Activity
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Epidermal Growth Factor Receptor Signaling Pathway
  • Erbb2 Signaling Pathway
  • Mapk Cascade
  • Negative Regulation Of Apoptotic Process
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Cell Differentiation
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Fibroblast Proliferation
  • Positive Regulation Of Mitotic Nuclear Division
  • Positive Regulation Of Urine Volume
  • Regulation Of Cell Motility
  • Regulation Of Phosphatidylinositol 3-Kinase Signaling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00892| AS27_09059| Bcn| betacellulin, epidermal growth factor family member| CB1_001109040| D623_10008857| EGK_15786| H920_12314| M91_08175| N300_02081| N302_13236| N303_14696| N305_08753| N307_15106| N325_10048| N330_08832| N331_08023| N332_10427| PANDA_007797| probetacellulin| probetacellulin-like| probetacellulin-like protein| UY3_09912| Y1Q_011714| Y956_11986| btc

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