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  3. BRD8

BRD8 (Bromodomain containing 8)

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The Function of BRD8

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

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Protein names

Recommended name:

Bromodomain-containing protein 8

Alternative name(s):

Skeletal muscle abundant protein
Skeletal muscle abundant protein 2
Thyroid hormone receptor coactivating protein of 120 kDa
TrCP120
p120

Top Gene-Substance Interactions

Substances That Increase BRD8

Substances Interaction Organism Category

Substances That Decrease BRD8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • PPAR-gamma1
  • PPAR-gamma2
  • Nkx2-2
  • FOXO3b

Tissue specificity:

Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Gene Pathways:

  • Chromatin organization

Caution:

It is uncertain whether Met-1 or Met-32 is the initiator.

Molecular Function:

  • Thyroid Hormone Receptor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Cell Surface Receptor Signaling Pathway
  • Histone H2a Acetylation
  • Histone H4 Acetylation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Growth
  • Regulation Of Transcription, Dna-Templated
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Signal Transduction
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Brd8-PA| bromodomain-containing protein 8| bromodomain-containing protein 8-like protein| CG14514 gene product from transcript CG14514-RA| CG14514-PA| dBrd8| Dmel_CG14514| H920_19235| M959_08336| MDA_GLEAN10012480| N306_11206| N307_13781| N324_09498| N339_02487| p120| PAL_GLEAN10016826| PANDA_011784| skeletal muscle abundant protein 2| SMAP| SMAP2| thyroid hormone receptor coactivating protein of 120 kDa| trCP120| UY3_11916| Y1Q_007535| brd8

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