The Function of BRD8
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Protein names
Recommended name:
Bromodomain-containing protein 8Alternative name(s):
Skeletal muscle abundant proteinSkeletal muscle abundant protein 2
Thyroid hormone receptor coactivating protein of 120 kDa
TrCP120
p120
Top Gene-Substance Interactions
Substances That Increase BRD8
Substances | Interaction | Organism | Category |
Substances That Decrease BRD8
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Gene Pathways:
Caution:
It is uncertain whether Met-1 or Met-32 is the initiator.
Molecular Function:
Biological Processes:
- Cell Surface Receptor Signaling Pathway
- Histone H2a Acetylation
- Histone H4 Acetylation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Growth
- Regulation Of Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Signal Transduction
- Transcription, Dna-Templated