Summary of BMP7
BMP7 encodes a protein that plays a role in bone, kidney and brown adipose tissue development. It helps induce bone formation and may promote fracture healing (R).
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The Function of BMP7
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Protein names
Recommended name:
Bone morphogenetic protein 7Short name:
OP-1Alternative name(s):
BMP-7Osteogenic protein 1
Eptotermin alfa
- RS182784 (BMP7) ??
- RS186660 (BMP7) ??
- RS6070035 (BMP7) ??
- RS6127983 (BMP7) ??
- RS6127984 (BMP7) ??
- RS8116259 (BMP7) ??
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Top Gene-Substance Interactions
BMP7 Interacts with These Diseases
| Disease | Score |
Substances That Increase BMP7
| Substances | Interaction | Organism | Category |
Substances That Decrease BMP7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the kidney and bladder. Lower levels seen in the brain.
Gene Pathways:
Developmental stage:
Expressed in the developing eye, brain and ear during embryogenesis.
Molecular Function:
- Cytokine Activity
- Transforming Growth Factor Beta Receptor Binding
- Heparin Binding
- Bmp Receptor Binding
Biological Processes:
- Skeletal System Development
- Ossification
- Metanephros Development
- Ureteric Bud Development
- Mesoderm Formation
- Mesonephros Development
- Epithelial To Mesenchymal Transition
- Endocardial Cushion Formation
- Pericardium Morphogenesis
- Axon Guidance
- Embryonic Pattern Specification
- Negative Regulation Of Striated Muscle Cell Apoptotic Process
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
- Dendrite Development
- Neural Fold Elevation Formation
- Embryonic Limb Morphogenesis
- Positive Regulation Of Bone Mineralization
- Bmp Signaling Pathway
- Epithelial Cell Differentiation
- Hindbrain Development
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Response To Estradiol
- Response To Vitamin D
- Positive Regulation Of Heterotypic Cell-Cell Adhesion
- Protein Localization To Nucleus
- Growth
- Negative Regulation Of Phosphorylation
- Negative Regulation Of Nf-Kappab Import Into Nucleus
- Odontogenesis Of Dentin-Containing Tooth
- Regulation Of Apoptotic Process
- Positive Regulation Of Apoptotic Process
- Steroid Hormone Mediated Signaling Pathway
- Negative Regulation Of Map Kinase Activity
- Response To Peptide Hormone
- Negative Regulation Of Neuron Differentiation
- Positive Regulation Of Osteoblast Differentiation
- Negative Regulation Of Notch Signaling Pathway
- Negative Regulation Of Cell Cycle
- Negative Regulation Of Mitotic Nuclear Division
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Embryonic Camera-Type Eye Morphogenesis
- Cardiac Muscle Tissue Development
- Branching Morphogenesis Of An Epithelial Tube
- Mesenchymal Cell Differentiation
- Neuron Projection Morphogenesis
- Cartilage Development
- Pharyngeal System Development
- Embryonic Skeletal Joint Morphogenesis
- Regulation Of Pathway-Restricted Smad Protein Phosphorylation
- Smad Protein Signal Transduction
- Cardiac Septum Morphogenesis
- Branching Involved In Salivary Gland Morphogenesis
- Mesenchyme Development
- Negative Regulation Of Cell Death
- Negative Regulation Of Prostatic Bud Formation
- Regulation Of Branching Involved In Prostate Gland Morphogenesis
- Chorio-Allantoic Fusion
- Heart Trabecula Morphogenesis
- Monocyte Aggregation
- Cellular Response To Hypoxia
- Cellular Response To Bmp Stimulus
- Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis
- Negative Regulation Of Glomerular Mesangial Cell Proliferation
- Metanephric Mesenchyme Morphogenesis
- Nephrogenic Mesenchyme Morphogenesis
- Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
- Positive Regulation Of Dendrite Development
- Positive Regulation Of Hyaluranon Cable Assembly
- Allantois Development
- Regulation Of Removal Of Superoxide Radicals