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  2. Genes
  3. BMP7

BMP7 (Bone morphogenetic protein 7)

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Summary of BMP7

BMP7 encodes a protein that plays a role in bone, kidney and brown adipose tissue development. It helps induce bone formation and may promote fracture healing (R). 

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The Function of BMP7

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Protein names

Recommended name:

Bone morphogenetic protein 7

Short name:

OP-1

Alternative name(s):

BMP-7
Osteogenic protein 1
Eptotermin alfa

BMP7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS182784 (BMP7) ??
  2. RS186660 (BMP7) ??
  3. RS6070035 (BMP7) ??
  4. RS6127983 (BMP7) ??
  5. RS6127984 (BMP7) ??
  6. RS8116259 (BMP7) ??

Top Gene-Substance Interactions

BMP7 Interacts with These Diseases

Disease Score

Substances That Increase BMP7

Substances Interaction Organism Category

Substances That Decrease BMP7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Meis-1
  • Nkx3-1 v1
  • Nkx3-1
  • Meis-1b

Tissue specificity:

Expressed in the kidney and bladder. Lower levels seen in the brain.

Gene Pathways:

  • Hedgehog signaling pathway
  • Cytokine-cytokine receptor interaction
  • TGF-beta signaling pathway
  • Extracellular matrix organization

Developmental stage:

Expressed in the developing eye, brain and ear during embryogenesis.

Molecular Function:

  • Bmp Receptor Binding
  • Cytokine Activity
  • Heparin Binding
  • Transforming Growth Factor Beta Receptor Binding

Biological Processes:

  • Allantois Development
  • Axon Guidance
  • Bmp Signaling Pathway
  • Branching Involved In Salivary Gland Morphogenesis
  • Branching Morphogenesis Of An Epithelial Tube
  • Cardiac Muscle Tissue Development
  • Cardiac Septum Morphogenesis
  • Cartilage Development
  • Cellular Response To Bmp Stimulus
  • Cellular Response To Hypoxia
  • Chorio-Allantoic Fusion
  • Dendrite Development
  • Embryonic Camera-Type Eye Morphogenesis
  • Embryonic Limb Morphogenesis
  • Embryonic Pattern Specification
  • Embryonic Skeletal Joint Morphogenesis
  • Endocardial Cushion Formation
  • Epithelial Cell Differentiation
  • Epithelial To Mesenchymal Transition
  • Growth
  • Heart Trabecula Morphogenesis
  • Hindbrain Development
  • Mesenchymal Cell Differentiation
  • Mesenchyme Development
  • Mesoderm Formation
  • Mesonephros Development
  • Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
  • Metanephric Mesenchyme Morphogenesis
  • Metanephros Development
  • Monocyte Aggregation
  • Negative Regulation Of Cell Cycle
  • Negative Regulation Of Cell Death
  • Negative Regulation Of Glomerular Mesangial Cell Proliferation
  • Negative Regulation Of Map Kinase Activity
  • Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis
  • Negative Regulation Of Mitotic Nuclear Division
  • Negative Regulation Of Neuron Differentiation
  • Negative Regulation Of Nf-Kappab Import Into Nucleus
  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of Notch Signaling Pathway
  • Negative Regulation Of Phosphorylation
  • Negative Regulation Of Prostatic Bud Formation
  • Negative Regulation Of Striated Muscle Cell Apoptotic Process
  • Negative Regulation Of Transcription, Dna-Templated
  • Nephrogenic Mesenchyme Morphogenesis
  • Neural Fold Elevation Formation
  • Neuron Projection Morphogenesis
  • Odontogenesis Of Dentin-Containing Tooth
  • Ossification
  • Pericardium Morphogenesis
  • Pharyngeal System Development
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Bone Mineralization
  • Positive Regulation Of Dendrite Development
  • Positive Regulation Of Heterotypic Cell-Cell Adhesion
  • Positive Regulation Of Hyaluranon Cable Assembly
  • Positive Regulation Of Osteoblast Differentiation
  • Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
  • Positive Regulation Of Peptidyl-Threonine Phosphorylation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Localization To Nucleus
  • Regulation Of Apoptotic Process
  • Regulation Of Branching Involved In Prostate Gland Morphogenesis
  • Regulation Of Pathway-Restricted Smad Protein Phosphorylation
  • Regulation Of Removal Of Superoxide Radicals
  • Response To Estradiol
  • Response To Peptide Hormone
  • Response To Vitamin D
  • Skeletal System Development
  • Smad Protein Signal Transduction
  • Steroid Hormone Mediated Signaling Pathway
  • Ureteric Bud Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

A306_08478| AS27_03213| AS28_06977| BMP5| BMP-7| bone moorphogenic protein-7| bone morphogenetic protein 5| bone morphogenetic protein 7 (osteogenic protein 1)| bone morphogenetic protein 7 preproprotein| bone morphoproteintic protein 7| CB1_000875028| EGK_02265| H920_07269| M959_06537| MDA_GLEAN10009909| N300_15748| N301_06110| N302_00400| N303_00743| N305_13226| N306_01697| N307_09866| N308_06825| N309_04635| N311_01760| N312_01969| N321_03076| N322_03671| N324_02738| N326_03650| N327_10945| N328_06715| N330_12564| N332_03298| N333_02179| N334_12374| OP1| OP-1| osteogenic protein 1| PAL_GLEAN10024532| PsBMP7| TREES_T100015649| UY3_07030| Y1Q_014111| Y956_12872| Z169_03693| bmp7

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