The Function of BIRC2
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
Protein names
Recommended name:
Baculoviral IAP repeat-containing protein 2Alternative name(s):
Cellular inhibitor of apoptosis 1C-IAP1
IAP homolog B
Inhibitor of apoptosis protein 2
hIAP-2
hIAP2
RING finger protein 48
RING-type E3 ubiquitin transferase BIRC2
TNFR2-TRAF-signaling complex protein 2
Top Gene-Substance Interactions
BIRC2 Interacts with These Diseases
| Disease | Score |
Substances That Increase BIRC2
| Substances | Interaction | Organism | Category |
Substances That Decrease BIRC2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
Gene Pathways:
Enzyme Regulation:
The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination.
Molecular Function:
- Transcription Coactivator Activity
- Ubiquitin-Protein Transferase Activity
- Zinc Ion Binding
- Transferase Activity
- Ligase Activity
- Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
- Ubiquitin Binding
- Protein N-Terminus Binding
- Fbxo Family Protein Binding
Biological Processes:
- Protein Polyubiquitination
- Response To Hypoxia
- Placenta Development
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
- Cell Surface Receptor Signaling Pathway
- I-Kappab Kinase/Nf-Kappab Signaling
- Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
- Regulation Of Necrotic Cell Death
- Tumor Necrosis Factor-Mediated Signaling Pathway
- Regulation Of Toll-Like Receptor Signaling Pathway
- Trif-Dependent Toll-Like Receptor Signaling Pathway
- Nik/Nf-Kappab Signaling
- Regulation Of Rig-I Signaling Pathway
- Regulation Of Cell Proliferation
- Regulation Of Apoptotic Process
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Regulation Of Innate Immune Response
- Response To Ethanol
- Regulation Of Cell Differentiation
- Regulation Of Inflammatory Response
- Protein Heterooligomerization
- Response To Camp
- Regulation Of Cell Cycle
- Regulation Of Necroptotic Process
- Necroptotic Process
- Regulation Of Nucleotide-Binding Oligomerization Domain Containing Signaling Pathway
- Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
- Positive Regulation Of Protein K63-Linked Ubiquitination
- Positive Regulation Of Protein K48-Linked Ubiquitination
- Positive Regulation Of Protein Monoubiquitination
- Inhibition Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Regulation Of Cysteine-Type Endopeptidase Activity
- Regulation Of Reactive Oxygen Species Metabolic Process