• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. BHLHE40

BHLHE40 (Basic helix-loop-helix family member e40)

Loading...

The Function of BHLHE40

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Class E basic helix-loop-helix protein 40

Short name:

DEC1

Alternative name(s):

bHLHe40
Class B basic helix-loop-helix protein 2
bHLHb2
Differentially expressed in chondrocytes protein 1
Enhancer-of-split and hairy-related protein 2
SHARP-2
Stimulated by retinoic acid gene 13 protein

BHLHE40 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS78745845 (BHLHE40) ??

Top Gene-Substance Interactions

BHLHE40 Interacts with These Diseases

Disease Score

Substances That Increase BHLHE40

Substances Interaction Organism Category

Substances That Decrease BHLHE40

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • AP-1
  • c-Jun
  • c-Fos
  • Egr-2
  • E4BP4

Tissue specificity:

Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.

Gene Pathways:

  • Circadian Clock
  • Mus musculus biological processes
  • Circadian rhythm - mammal

Molecular Function:

  • Bhlh Transcription Factor Binding
  • E-Box Binding
  • Mrf Binding
  • Protein Domain Specific Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Rna Polymerase Ii Activating Transcription Factor Binding
  • Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Factor Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Circadian Regulation Of Gene Expression
  • Entrainment Of Circadian Clock By Photoperiod
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| basic helix-loop-helix family, member e40| A306_11226| AS27_07325| basic helix-loop-helix domain containing, class B2| basic helix-loop-helix domain containing, class B, 2| basic helix-loop-helix domain containing class B2 protein| basic helix-loop-helix domain-containing protein class B2| BHLHB2| bHLH protein DEC1| CB1_000828005| class B basic helix-loop-helix protein 2| Class B basic helix-loop-helix protein 2 isoform 3-like protein| Class E basic helix-loop-helix protein 40| Clast5| CR8| cytokine response gene 8| DEC1| differentially expressed in chondrocytes 1| differentially expressed in chondrocytes protein 1| differentiated embryo chondrocyte expressed gene 1| E47 interaction protein 1| EGK_11468| EH28_24784| eip1 (E47 interaction protein 1)| enhancer-of-split and hairy-related protein 2| GW7_20260| H920_06166| HLHB2| M959_07729| MDA_GLEAN10023248| N300_04392| N301_10549| N302_16135| N303_14472| N305_14737| N306_02093| N307_08421| N308_15397| N309_11066| N312_09085| N321_07884| N322_09697| N324_10639| N327_04260| N328_08917| N330_09039| N331_06602| N332_12224| N334_07422| N335_08657| N339_00052| PAL_GLEAN10009280| PANDA_008712| SHARP2| SHARP-2| stimulated by retinoic acid 14| stimulated by retinoic acid gene 13 protein| STRA13| stra14| TREES_T100007093| UY3_08440| Y1Q_006549| Y956_14439| Z169_04878| bhlhe40

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved