The Function of BHLHE40
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
Protein names
Recommended name:
Class E basic helix-loop-helix protein 40Short name:
DEC1Alternative name(s):
bHLHe40Class B basic helix-loop-helix protein 2
bHLHb2
Differentially expressed in chondrocytes protein 1
Enhancer-of-split and hairy-related protein 2
SHARP-2
Stimulated by retinoic acid gene 13 protein
- RS78745845 (BHLHE40) ??
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Top Gene-Substance Interactions
BHLHE40 Interacts with These Diseases
| Disease | Score |
Substances That Increase BHLHE40
| Substances | Interaction | Organism | Category |
Substances That Decrease BHLHE40
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Molecular Function:
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Activating Transcription Factor Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Corepressor Activity
- Protein Domain Specific Binding
- Protein Homodimerization Activity
- Bhlh Transcription Factor Binding
- Mrf Binding
- Protein Heterodimerization Activity
- E-Box Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Circadian Regulation Of Gene Expression
- Entrainment Of Circadian Clock By Photoperiod
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated