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  3. BCOR

BCOR (BCL6 corepressor)

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The Function of BCOR

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).

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Protein names

Recommended name:

BCL-6 corepressor

Alternative name(s):

BCoR

BCOR SNPs

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  1. RS17145638 (BCOR) ??

Top Gene-Substance Interactions

BCOR Interacts with These Diseases

Disease Score

Substances That Increase BCOR

Substances Interaction Organism Category

Substances That Decrease BCOR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-6
  • Pax-2
  • Pax-2b

Tissue specificity:

Ubiquitously expressed.

Molecular Function:

  • Heat Shock Protein Binding
  • Histone Deacetylase Binding
  • Transcription Corepressor Activity
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Heart Development
  • Histone H2a Monoubiquitination
  • Negative Regulation Of Bone Mineralization
  • Negative Regulation Of Histone H3-K36 Methylation
  • Negative Regulation Of Histone H3-K4 Methylation
  • Negative Regulation Of Tooth Mineralization
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Odontogenesis
  • Palate Development
  • Specification Of Axis Polarity
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_19020| ANOP2| AS27_04938| AS28_14869| BCL-6 corepressor| BCL6 co-repressor| BCL-6 corepressor short isoform| Bcl6 interacting corepressor| BCL-6 interacting corepressor| BcorR| D623_10023315| H920_10363| I79_000573| M91_17204| M959_13691| MAA2| MCOPS2| MDA_GLEAN10013838| N300_03952| N301_04911| N305_07987| N306_07299| N307_02037| N308_06897| N309_13709| N326_09185| N328_04670| N330_04625| N331_08909| N332_13269| PAL_GLEAN10005758| PANDA_001330| RGD1562735| TREES_T100013131| UY3_11433| xtBcor| Y1Q_010368| Z169_14662| bcor

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