The Function of BCOR
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Protein names
Recommended name:
BCL-6 corepressorAlternative name(s):
BCoR- RS17145638 (BCOR) ??
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Top Gene-Substance Interactions
BCOR Interacts with These Diseases
| Disease | Score |
Substances That Increase BCOR
| Substances | Interaction | Organism | Category |
Substances That Decrease BCOR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed.
Molecular Function:
- Transcription Corepressor Activity
- Transcription Factor Binding
- Heat Shock Protein Binding
- Histone Deacetylase Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Histone H3-K36 Methylation
- Transcription, Dna-Templated
- Heart Development
- Negative Regulation Of Bone Mineralization
- Histone H2a Monoubiquitination
- Odontogenesis
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Histone H3-K4 Methylation
- Palate Development
- Specification Of Axis Polarity
- Negative Regulation Of Tooth Mineralization