Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     Covered on Genetics Home Reference: 1q21.1 microdeletionFrom UniProt: A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.

     From NCBI Gene: BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008] From UniProt: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• c-Myc

Tissue specificity:

Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood.

Caution:

It is uncertain whether Met-1 or Met-27 is the initiator.

Biological Processes:

• Beta-Catenin-Tcf Complex Assembly
• Canonical Wnt Signaling Pathway
• Myotube Differentiation Involved In Skeletal Muscle Regeneration
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Skeletal Muscle Cell Differentiation
• Somatic Stem Cell Population Maintenance

*synonyms